0
Editor's Correspondence |

Chocolate Consumption and Effects on Serotonin Synthesis—Reply

Beatrice A. Golomb, MD, PhD; Sabrina Koperski, BS; Natalie Rose, MD
Arch Intern Med. 2010;170(17):1608-1609. doi:10.1001/archinternmed.2010.332.
Text Size: A A A
Published online

Extract

In reply

Carrieri et al observe that chocolate abstainers, among those with HIV-HCV coinfection, are more likely to become depressed. This underscores 2 important issues: abstainer effects and effect modification (“confection vs coinfection”).

Persons who abstain from chocolate may do so for a reason. This reason, rather than lack of chocolate, may relate to higher depression risk. For instance, those who forswear chocolate because of caffeine (or methylxanthine) intolerance may also renounce coffee and lose the marked liver protections coffee purportedly affords.1 This may hasten liver compromise in HCV, itself linked to depression,2 and may increase prospects of HCV treatment,3 typically interferon alfa, for which depression is a well-recognized adverse effect.4 (This may also increase vulnerability to hepatically cleared drugs and chemicals, some with depressogenic effects such as alcohol, which is an issue in this HCV population.)

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

September 27, 2010
Beatrice A. Golomb, MD, PhD; Sabrina Koperski, BS; Natalie Rose, MD
Arch Intern Med. 2010;170(17):1608-1609. doi:10.1001/archinternmed.2010.332.
September 27, 2010
Nuno Rodrigues Silva, MMed
Arch Intern Med. 2010;170(17):1608-1609. doi:10.1001/archinternmed.2010.331.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();