0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Chocolate Consumption and Effects on Serotonin Synthesis—Reply

Beatrice A. Golomb, MD, PhD; Sabrina Koperski, BS; Natalie Rose, MD
Arch Intern Med. 2010;170(17):1608-1609. doi:10.1001/archinternmed.2010.332.
Text Size: A A A
Published online

Extract

In reply

Carrieri et al observe that chocolate abstainers, among those with HIV-HCV coinfection, are more likely to become depressed. This underscores 2 important issues: abstainer effects and effect modification (“confection vs coinfection”).

Persons who abstain from chocolate may do so for a reason. This reason, rather than lack of chocolate, may relate to higher depression risk. For instance, those who forswear chocolate because of caffeine (or methylxanthine) intolerance may also renounce coffee and lose the marked liver protections coffee purportedly affords.1 This may hasten liver compromise in HCV, itself linked to depression,2 and may increase prospects of HCV treatment,3 typically interferon alfa, for which depression is a well-recognized adverse effect.4 (This may also increase vulnerability to hepatically cleared drugs and chemicals, some with depressogenic effects such as alcohol, which is an issue in this HCV population.)

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

September 27, 2010
Beatrice A. Golomb, MD, PhD; Sabrina Koperski, BS; Natalie Rose, MD
Arch Intern Med. 2010;170(17):1608-1609. doi:10.1001/archinternmed.2010.332.
September 27, 2010
Nuno Rodrigues Silva, MMed
Arch Intern Med. 2010;170(17):1608-1609. doi:10.1001/archinternmed.2010.331.
CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();