In a Cox proportional hazards model adjusted for age, sex, and race, high CRP level, as defined by the CDC/AHA cut point of >3.0 mg/L was associated with a significant increase in risk (HR, 2.70; 95% CI, 1.69-4.31) (Table 2). After further adjustment for smoking status, systolic blood pressure, LDL-C and HDL-C levels, and diabetes, the risk associated with high CRP level remained significantly increased (HR, 1.87; 95% CI, 1.13-3.10) (Table 3). Levels of Lp-PLA2 in the highest tertile (≥422 μg/L) were associated with an increased risk for incident ischemic stroke (HR, 2.23; 95% CI, 1.48-3.34) in a model adjusted for age, sex, and race. In a Cox proportional hazards model also adjusted for traditional risk factors of smoking status, systolic blood pressure, LDL-C and HDL-C levels, and diabetes, high levels of Lp-PLA2 were still associated with a significant increase in risk for incident ischemic stroke (HR, 1.91; 95% CI, 1.15-3.18), and this association remained significant if CRP was included in the model (HR, 1.97; 95% CI, 1.16-3.33). Addition of antihypertensive medication and BMI to the model also did not change the results (HR, 1.93; 95% CI, 1.14-3.27); results were similar when the waist-hip ratio was substituted for BMI. Hazard ratios were similar for all incident stroke (data not shown). In the fully adjusted model, blood pressure, diabetes, current smoking, age, and race were all significant predictors of ischemic stroke, whereas LDL-C and HDL-C levels and sex were not.