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Editorial |

When Is a New Prediction Marker Useful?  A Consideration of Lipoprotein-Associated Phospholipase A2 and C-Reactive Protein for Stroke Risk

Philip Greenland, MD; Patrick G. O’Malley, MC, USA
Arch Intern Med. 2005;165(21):2454-2456. doi:10.1001/archinte.165.21.2454.
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Ischemic stroke is a common and often devastating condition that can cause significant disability or death. In light of the dire consequences of a completed stroke, the search for improved predictive models and new markers to identify patients at heightened risk is well justified. Such high-risk patients would be candidates for proven stroke-prevention therapies including aspirin,1 antihypertensive medications, and HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors.2

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Receiver operating characteristic curves: a perfect test has an area under the curve (AUC) of 1.0, while a worthless test has an area of 0.5. The AUC indicates the probabillity of being able to discriminate randomly selected affected and unaffected persons solely on the basis of their scores.

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