We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Practicing Medicine at the Front Lines of the Genomic Revolution

Wendy S. Rubinstein, MD, PhD; Hemant K. Roy, MD
Arch Intern Med. 2005;165(16):1815-1817. doi:10.1001/archinte.165.16.1815.
Text Size: A A A
Published online


There is unequivocal evidence that most common illnesses, such as coronary atherosclerosis, diabetes, many cancers, obesity, and certain psychiatric diseases (eg, schizophrenia), are due to interactions between multiple genetic and environmental factors. While humans are 99.9% genetically alike, the dissimilarities of the remaining 0.1% of the human genome contribute importantly to the occurrence of human disease. These differences are composed of about 10 million common variants (present in 1% or more of alleles) and many more rare variants. Numerous reports have implicated genetic variations in the propensity toward (or resistance to) illness and the response to medical treatment. There has been considerable success in the use of genomics for mendelian disorders such as cystic fibrosis, Huntington disease, and hereditary breast-ovarian cancer (BRCA1 and BRCA2). However, many of the most common disorders lack simple mendelian inheritance and are impacted by multiple genetic events along with complex nongenetic modulators (eg, epigenetic events from environmental factors). The Human Genome Diversity Project aims to catalog and study human variation, thereby shedding light on complex illnesses.1



Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

6 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles