The Profile of Female Sexual Function (PFSF) is a validated, 37-item, self-administered questionnaire that measures 7 domains of sexual function (desire, pleasure, arousal, responsiveness, self-image, orgasm, and concerns) and was designed specifically for use in postmenopausal women with low sexual desire.18,19 Scores of 0, 20, 40, 60, 80, and 100 on each domain of the PFSF correspond, on average, to the following categories of response: “never,” “seldom,” “sometimes,” “often,” “very often,” and “always,” respectively. An increase in the sexual concerns score indicated a decrease in patients’ concerns related to sexuality. The Sexual Activity Log, a 1-week recall diary, records the number of intercourse and nonintercourse sexual events, the number of orgasms, and the number of sexual events that were satisfying.20 Changes in sexual desire and in frequency of satisfying sexual activity were primary end points. The Personal Distress Scale (PDS) is a 7-item, self-administered questionnaire designed to assess the level of distress associated with a woman’s sexual function.21 It was developed and validated in parallel with the PFSF and queries the woman about personal feelings regarding her interest or lack of interest in sex. Scores of 0, 20, 40, 60, 80, and 100 on the PDS correspond, on average, to the following categories of response: “never,” “seldom,” “sometimes,” “often,” “very often,” and “always” distressed about a lack of interest in sex, respectively. A decrease in PDS score indicated a decrease in patient distress.