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Original Investigation |

Increased Prevalence of Celiac Disease in Patients With Dyspepsia FREE

Maria Teresa Bardella, MD; Giorgio Minoli, MD; Davide Ravizza, MD; Franco Radaelli, MD; Pietro Velio, MD; Maurizio Quatrini, MD; Paolo A. Bianchi, MD; Dario Conte, MD
[+] Author Affiliations

From the Cattedra di Gastroenterologia, Istituto di Scienze Mediche, IRCCS Ospedale Maggiore, Milano (Drs Bardella, Ravizza, Velio, Quatrini, Bianchi, and Conte), and the Divisione di Gastroenterologia, Ospedale Valduce, Como (Drs Minoli and Radaelli), Italy.


Arch Intern Med. 2000;160(10):1489-1491. doi:10.1001/archinte.160.10.1489.
Text Size: A A A
Published online

Background  Although 30% to 40% of patients with celiac disease (CD) (which affects 1 in 200 individuals) have dyspeptic symptoms, there is a lack of data concerning the prevalence of CD in patients with dyspepsia.

Methods  In this prospective series, we enrolled all consecutive outpatients undergoing endoscopy of the upper gastrointestinal tract for dyspepsia at our centers between January and June 1998. The exclusion criteria were age younger than 12 years, workup or follow-up of an already known disease of the gastrointestinal tract, suspected CD, malabsorption, and/or iron-deficiency anemia.

Results  Of the 3019 patients who were evaluated, 517 (17%) were eligible for the study. Endoscopic findings suggested CD in 5 cases. Celiac disease was histologically diagnosed in 6 patients (5 women and 1 man; mean age, 31.3 years; age range, 20-46 years), 3 of whom had a normal endoscopic pattern and 3 of whom had an endoscopic pattern that was consistent with CD. In the patients with histologically diagnosed CD, antiendomysium antibody positivity supported the diagnosis. The relative risk for CD was 2.32 (95% confidence interval, 1.06-5.07) in comparison with the general population and higher among females (3.22; 95% confidence interval, 1.37-7.56).

Conclusions  The present results indicate that the prevalence of CD in patients with dyspepsia is twice that of the general population. Thus, serological screening for CD should be considered in the early workup of these patients to allow diagnosis and treatment of an eminently treatable disease.

CELIAC DISEASE (CD) is characterized by a wide range of intestinal and/or extraintestinal manifestations that, in susceptible individuals, are attributable to the toxic action of the gluten present in wheat, rye, and barley.1 As defined according to recent reviews,2,3 dyspeptic symptoms are reported by a number of patients with CD4 and may represent the only manifestation of a disease that affects 1 in 200 subjects in most series from Western countries57; the prevalence is similar in Italy.8,9 However, despite this, there are no data concerning the prevalence of CD in patients with dyspepsia, to our knowledge. This fact is surprising given that a gluten-free diet is highly successful in normalizing clinical and histologic abnormalities,10 thus preventing severe and life-threatening CD complications, such as lymphoma or ulcerative jejunoileitis,11 and avoiding further useless examinations and/or empirical management.

The present prospective study was therefore designed to evaluate the prevalence of CD in a large series of patients with dyspepsia who were undergoing duodenal biopsy and endoscopy of the upper gastrointestinal tract (GI).

STUDY POPULATION

Between January and June 1998, all the outpatients attending the GI units of 2 tertiary centers in Lombardy (northern Italy) for upper GI tract endoscopy because of dyspeptic symptoms (chronic or recurrent pain or discomfort centered in the upper area of the abdomen) were prospectively studied. Excluded were patients younger than 12 years; those undergoing clinical workup for an upper GI tract disease suggested by previous radiographic or ultrasonographic findings; those referred for malabsorption, suspected celiac disease, or iron deficiency anemia; those receiving regular follow-up for a known disease (eg, peptic ulcer); and those with classic heartburn or acid regurgitation. All patients who fulfilled the inclusion criteria gave their informed consent for upper GI tract endoscopy and histologic sampling. The study was approved by the Ethics Committee of both centers. The endoscopic findings were classified as normal, consistent with peptic lesions (in the presence of esophagitis, mucosal reddening with erosions, or ulcers), positive for polyps and/or tumors, suggestive of CD (in the case of a loss or reduction in duodenal folds, a nodular or mosaic mucosal pattern, or duodenal fold scalloping),12,13 or miscellaneous (hiatal hernia, varices, etc). Four duodenal mucosal samples (2 from 2 cm above and 2 from 2 cm below the major duodenal papilla) were obtained from all patients during upper GI tract endoscopy (using GIF-100; Olympus Optical Co, Tokyo, Japan), with further samples being obtained when considered necessary, ie, in the presence of macroscopic appearances consistent with esophagitis, gastritis, and/or duodenitis. The biopsy specimens were oriented, routinely processed, stained with hematoxylin-eosin and periodic acid–Schiff, and blindly examined by two of us (M.T.B. and P.V.) independently. The diagnosis of CD was based on the presence of villous atrophy, crypt hyperplasia, and an increased number of lymphocytes in the epithelium and lamina propria14; the presence of Helicobacter pylori was also always searched for histologically. All patients with a histologic diagnosis of CD also underwent standard nephelometric serological immunoglobulin determinations and IgA antiendomysium antibody measurements obtained by indirect immunofluorescence (Eurospital, Trieste, Italy) and were put on a gluten-free diet and followed up.

STATISTICAL METHODS

Descriptive statistics (mean, SD, minimum, and maximum) were calculated together with relative risks and 95% confidence intervals.15

Five hundred thirty-three of the 3019 prospectively evaluated patients complied with the inclusion criteria, but 16 were excluded because of the inadequacy of the duodenal samples taken for histologic processing. The analysis was therefore based on the biopsy specimens obtained from 517 patients, representing 17% of the entire group (207 males and 310 females; mean ± SD age, 49.9 ± 16 years; age range, 14-88 years).

The endoscopic findings were normal in 311 cases (60%), showed peptic lesion(s) in 132 (26%), demonstrated polyp(s) or tumors in 13 (2%), were suggestive of CD in 5 (1%), and were miscellaneous in 56 (11%). Celiac disease was histologically diagnosed in 6 patients (1.2%), 3 of whom had a normal duodenal endoscopic pattern (false-negative results), and 3 of whom had an endoscopic pattern suggestive of CD. The sensitivity of the endoscopic markers for CD was therefore 50%. The loss of duodenal folds in 2 other cases suggested CD, but the diagnosis was not histologically confirmed.

The demographic, endoscopic, histologic, and serological characteristics of the 6 patients with CD (3 diagnosed in Milan and 3 in Como) are shown in Table 1. All 6 patients were antiendomysium antibody positive; their ages ranged from 20 to 46 years (mean±SD age, 31.3 ± 9.5 years); and 5 were female. None of them presented any histologic evidence of H pylori. There was absolute agreement between the 2 pathologists in diagnosing or excluding CD.

Table Graphic Jump LocationCharacteristics of the 6 Patients With Celiac Disease

The present results indicate that patients with dyspepsia have an increased risk for CD and that the endoscopic duodenal markers suggestive of the disease are not sufficient to confirm or rule out its presence.

Over recent years, in addition to serological markers,16 increased attention has been given to some endoscopic findings that may be suggestive of CD (eg, loss, reduction, or scalloping of duodenal folds and/or a nodular or mosaic mucosal pattern). The data from different studies indicate a sensitivity of 73% to 100%, a specificity of 83% to 99%, and a positive predictive value of 85% to 91% for the above-mentioned markers.12,13,1719 However, some of these results may reflect a selection bias (most of the studies included patients undergoing specific workup for overt malabsorption and/or suspected CD), and the series that included patients without CD were strongly biased because duodenal biopsy specimens were obtained only in the presence of one or more of the so-called typical endoscopic CD markers.

In our study, multiple duodenal samples were obtained from all patients who underwent upper GI endoscopy for dyspepsia, and, despite the long training of the endoscopists involved, the overall diagnostic sensitivity of the endoscopic marker(s) was only 50%.

Celiac disease has a wide spectrum of clinical manifestations, ranging from symptomless to atypical forms and even severe malabsorption,1,20,21 and dyspepsia may be one of its symptoms.4,13 Our data clearly indicate that patients with dyspepsia are at definite risk for CD: its prevalence was more than twice that reported in general populations from the same geographical areas and most Western countries.59 Interestingly, the subgroup of dyspeptic patients at the highest risk comprised young women: 5 of the 6 patients with CD were women aged 20 to 37 years, and compared with the general population, their relative risk of CD was 3.22 (95% confidence interval, 1.37-7.56). The early diagnosis of CD is advisable because of the high prevalence of the disease and the beneficial effect of a gluten-free diet in decreasing the risk of intestinal lymphoma11 and other complications,10,22,23 which worsen the quality of life and lead to an increase in costs owing to useless examinations or supportive therapies.24,25

Our results suggest that the workup of patients with dyspepsia could be modified. It is well known that an organic cause is found in only 40% of cases26 and that the findings of clinical history and physical examination cannot reliably help in differentiating organic from functional dyspepsia,27 which explains the current controversy as to whether all patients with dyspepsia should undergo early endoscopy or start with empirical therapy.2730 In fact, although 30% to 60% of these patients have H pylori–related gastritis, there is still uncertainty as to whether the infection is responsible for the symptoms or whether eradication treatment induces a clinical improvement.3133

Although it is beyond the scope of this study to discuss the approach to dyspepsia (which needs to be evaluated by means of prospective studies based on cost-benefit analysis), we believe that our results justify modifying the guidelines recommended by recently reported consensus statements.27 In the case of patients with dyspepsia who are older than 45 years or those considered to be at risk for gastric cancer and for whom early endoscopy is advisable, it would be useful to obtain additional duodenal samples because of the possibility of false-negative endoscopic results: this simple procedure can rule out CD on the basis of subsequent histologic findings. Patients who are younger than 45 years and who show no signs or symptoms of an underlying organic disorder should be serologically examined for CD before costly and empirical treatment is begun. As shown by our results and those of a study based on data from an open-access endoscopy unit,34 this approach seems to be particularly appropriate for females. Serological CD screening can be based on the determination of antiendomysium antibodies, which, in addition to being the most sensitive and specific test currently available,35 is relatively inexpensive, even for screening large series of patients, because of the possibility of detecting antiendomysium antibodies using human umbilical cord or umbilical vein endothelial cells.36

In conclusion, serological CD screening should be considered in the early diagnostic workup of patients with dyspepsia (especially female patients) who are younger than 45 years to ensure that such a frequent disorder as CD is not missed.

Accepted for publication October 14, 1999.

This study was supported in part by grants from the CARIPLO Foundation, the Associazione Amici della Gastroenterologia Granelli, and the Associazione Italiana Celiachia, Milan, Italy.

The authors are indebted to Bruno M. Cesana, MD (Epidemiology Unit, IRCCS Ospedale Maggiore, Milan, Italy), for performing the statistical analysis and to Claudia Terrani for processing the histologic samples (Cattedra di Gastroenterologia, IRCCS Ospedale Maggiore).

Reprints: Maria Teresa Bardella, MD, Cattedra di Gastroenterologia, Padiglione Granelli, Via F. Sforza 35, 20122 Milano, Italy.

Trier  JS Celiac sprue. N Engl J Med. 1991;3251709- 1719
Link to Article
Talley  NJZinsmeister  ARSchleck  CDMelton  LJ Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology. 1992;1021259- 1268
Friedman  LS Helicobacter pylori and nonulcer dyspepsia. N Engl J Med. 1998;3391928- 1930
Link to Article
Ciacci  CCirillo  MSollazzo  RSavino  GSabbatini  FMazzacca  G Gender and clinical presentation in adult celiac disease. Scand J Gastroenterol. 1995;301077- 1081
Link to Article
Grodzinsky  EFranzen  LHed  JStrom  M High prevalence of celiac disease in healthy adults revealed by antigliadin antibodies. Ann Allergy. 1992;6966- 70
Ascher  HKristiansson  B Childhood coeliac disease in Sweden. Lancet. 1994;344340- 341
Link to Article
Fasano  A Where have all the American celiacs gone? Acta Paediatr Suppl. 1996;41220- 24
Link to Article
Catassi  CRatsch  IMFabiani  E  et al.  Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994;343200- 203
Link to Article
Catassi  CFabiani  ERatsch  IM  et al.  The coeliac iceberg in Italy: a multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl. 1996;41229- 35
Link to Article
Bardella  MTMolteni  NPrampolini  L  et al.  Need for follow up in coeliac disease. Arch Dis Child. 1994;70211- 213
Link to Article
Holmes  GKTPrior  PLane  MR  et al.  Malignancy in coeliac disease: effect of a gluten-free diet. Gut. 1989;30333- 338
Link to Article
Brocchi  ECorazza  GRCaletti  GTreggiari  EABarbara  LGasbarrini  G Endoscopic demonstration of loss of duodenal folds in the diagnosis of celiac disease. N Engl J Med. 1988;319741- 744
Link to Article
Jabbari  MWild  GGoresky  CA  et al.  Scalloped valvulae conniventes: an endoscopic marker of celiac sprue. Gastroenterology. 1988;951518- 1522
Marsh  MNCrowe  PT Morphology of the mucosal lesion in gluten sensitivity. Baillieres Clin Gastroenterol. 1995;9273- 293
Link to Article
Kahn  HASempos  CT Relative risk and odds ratio. Statistical Methods in Epidemiology. New York, NY Oxford University Press Inc1989;45- 71
Maki  MCollin  P Coeliac disease. Lancet. 1997;3491755- 1759
Link to Article
McIntyre  ASNg  DPKSmith  JAAmoah  JLong  RG The endoscopic appearance of duodenal folds is predictive of untreated adult celiac disease. Gastrointest Endosc. 1992;38148- 151
Link to Article
Maurino  ECapizzano  HNiveloni  S  et al.  Value of endoscopic markers in celiac disease. Dig Dis Sci. 1993;382028- 2033
Link to Article
Magazzù  GBottari  MTuccari  G  et al.  Upper gastrointestinal endoscopy can be a reliable screening tool for celiac sprue in adults. J Clin Gastroenterol. 1994;19255- 258
Link to Article
Corazza  GRFrisoni  MTreggiari  EA  et al.  Subclinical celiac sprue. J Clin Gastroenterol. 1993;1616- 21
Link to Article
Bardella  MTFraquelli  MQuatrini  MMolteni  NBianchi  PConte  D Prevalence of hypertransaminasemia in adult celiac disease and effect of gluten-free diet. Hepatology. 1995;22833- 836
Wright  DH The major complications of coeliac disease. Baillieres Clin Gastroenterol. 1995;9351- 369
Link to Article
Molteni  NCaraceni  MPBardella  MTOrtolani  SGandolini  GGBianchi  P Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood. Am J Gastroenterol. 1990;8551- 53
Dickey  WMcConnell  JB How many hospital visits does it take before celiac sprue is diagnosed? J Clin Gastroenterol. 1996;2321- 23
Link to Article
Hin  HBird  GFisher  PMahy  NJewell  D Coeliac disease in primary care: a case finding study. BMJ. 1999;318164- 167
Link to Article
Not Available, American Gastroenterological Association medical position statement: evaluation of dyspepsia Gastroenterology. 1998;114579- 581
Link to Article
Fisher  RSParkman  HP Management of nonulcer dyspepsia. N Engl J Med. 1998;3391376- 1381
Link to Article
Talley  NJColin-Jones  DKoch  KLKoch  MNyren  OStanghellini  V Functional dyspepsia: a classification with guidelines for diagnosis and management. Gastroenterol Int. 1991;4145- 146
Talley  NJSilverstein  MDAgréus  LNyren  OSonnenberg  AHoltmann  G Evaluation of dyspepsia. Gastroenterology. 1998;114582- 595
Link to Article
Mullins  PDColin-Jones  DG Guidelines for the management of dyspepsia. Eur J Gastrointerol Hepatol. 1999;11215- 217
Link to Article
McColl  KMurray  LEl-Omar  E  et al.  Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;3391869- 1874
Link to Article
Blum  ALTalley  NJO'Morain  C  et al.  Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;3391875- 1881
Link to Article
Friedman  LS Helicobacter pylori and nonulcer dyspepsia. N Engl J Med. 1998;3391928- 1930
Link to Article
Dickey  W Diagnosis of coeliac disease at open-access endoscopy. Scand J Gastroenterol. 1998;33612- 615
Link to Article
Volta  UMolinaro  NDe Franceschi  LFratangelo  DBianchi  FB IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Dig Dis Sci. 1995;401902- 1905
Link to Article
Whelan  AWilloughby  RWeir  D Human umbilical vein endothelial cells: a new easily available source of endomysial antigens. Eur J Gastroenterol Hepatol. 1996;8961- 966
Link to Article

Figures

Tables

Table Graphic Jump LocationCharacteristics of the 6 Patients With Celiac Disease

References

Trier  JS Celiac sprue. N Engl J Med. 1991;3251709- 1719
Link to Article
Talley  NJZinsmeister  ARSchleck  CDMelton  LJ Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology. 1992;1021259- 1268
Friedman  LS Helicobacter pylori and nonulcer dyspepsia. N Engl J Med. 1998;3391928- 1930
Link to Article
Ciacci  CCirillo  MSollazzo  RSavino  GSabbatini  FMazzacca  G Gender and clinical presentation in adult celiac disease. Scand J Gastroenterol. 1995;301077- 1081
Link to Article
Grodzinsky  EFranzen  LHed  JStrom  M High prevalence of celiac disease in healthy adults revealed by antigliadin antibodies. Ann Allergy. 1992;6966- 70
Ascher  HKristiansson  B Childhood coeliac disease in Sweden. Lancet. 1994;344340- 341
Link to Article
Fasano  A Where have all the American celiacs gone? Acta Paediatr Suppl. 1996;41220- 24
Link to Article
Catassi  CRatsch  IMFabiani  E  et al.  Coeliac disease in the year 2000: exploring the iceberg. Lancet. 1994;343200- 203
Link to Article
Catassi  CFabiani  ERatsch  IM  et al.  The coeliac iceberg in Italy: a multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl. 1996;41229- 35
Link to Article
Bardella  MTMolteni  NPrampolini  L  et al.  Need for follow up in coeliac disease. Arch Dis Child. 1994;70211- 213
Link to Article
Holmes  GKTPrior  PLane  MR  et al.  Malignancy in coeliac disease: effect of a gluten-free diet. Gut. 1989;30333- 338
Link to Article
Brocchi  ECorazza  GRCaletti  GTreggiari  EABarbara  LGasbarrini  G Endoscopic demonstration of loss of duodenal folds in the diagnosis of celiac disease. N Engl J Med. 1988;319741- 744
Link to Article
Jabbari  MWild  GGoresky  CA  et al.  Scalloped valvulae conniventes: an endoscopic marker of celiac sprue. Gastroenterology. 1988;951518- 1522
Marsh  MNCrowe  PT Morphology of the mucosal lesion in gluten sensitivity. Baillieres Clin Gastroenterol. 1995;9273- 293
Link to Article
Kahn  HASempos  CT Relative risk and odds ratio. Statistical Methods in Epidemiology. New York, NY Oxford University Press Inc1989;45- 71
Maki  MCollin  P Coeliac disease. Lancet. 1997;3491755- 1759
Link to Article
McIntyre  ASNg  DPKSmith  JAAmoah  JLong  RG The endoscopic appearance of duodenal folds is predictive of untreated adult celiac disease. Gastrointest Endosc. 1992;38148- 151
Link to Article
Maurino  ECapizzano  HNiveloni  S  et al.  Value of endoscopic markers in celiac disease. Dig Dis Sci. 1993;382028- 2033
Link to Article
Magazzù  GBottari  MTuccari  G  et al.  Upper gastrointestinal endoscopy can be a reliable screening tool for celiac sprue in adults. J Clin Gastroenterol. 1994;19255- 258
Link to Article
Corazza  GRFrisoni  MTreggiari  EA  et al.  Subclinical celiac sprue. J Clin Gastroenterol. 1993;1616- 21
Link to Article
Bardella  MTFraquelli  MQuatrini  MMolteni  NBianchi  PConte  D Prevalence of hypertransaminasemia in adult celiac disease and effect of gluten-free diet. Hepatology. 1995;22833- 836
Wright  DH The major complications of coeliac disease. Baillieres Clin Gastroenterol. 1995;9351- 369
Link to Article
Molteni  NCaraceni  MPBardella  MTOrtolani  SGandolini  GGBianchi  P Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood. Am J Gastroenterol. 1990;8551- 53
Dickey  WMcConnell  JB How many hospital visits does it take before celiac sprue is diagnosed? J Clin Gastroenterol. 1996;2321- 23
Link to Article
Hin  HBird  GFisher  PMahy  NJewell  D Coeliac disease in primary care: a case finding study. BMJ. 1999;318164- 167
Link to Article
Not Available, American Gastroenterological Association medical position statement: evaluation of dyspepsia Gastroenterology. 1998;114579- 581
Link to Article
Fisher  RSParkman  HP Management of nonulcer dyspepsia. N Engl J Med. 1998;3391376- 1381
Link to Article
Talley  NJColin-Jones  DKoch  KLKoch  MNyren  OStanghellini  V Functional dyspepsia: a classification with guidelines for diagnosis and management. Gastroenterol Int. 1991;4145- 146
Talley  NJSilverstein  MDAgréus  LNyren  OSonnenberg  AHoltmann  G Evaluation of dyspepsia. Gastroenterology. 1998;114582- 595
Link to Article
Mullins  PDColin-Jones  DG Guidelines for the management of dyspepsia. Eur J Gastrointerol Hepatol. 1999;11215- 217
Link to Article
McColl  KMurray  LEl-Omar  E  et al.  Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;3391869- 1874
Link to Article
Blum  ALTalley  NJO'Morain  C  et al.  Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. N Engl J Med. 1998;3391875- 1881
Link to Article
Friedman  LS Helicobacter pylori and nonulcer dyspepsia. N Engl J Med. 1998;3391928- 1930
Link to Article
Dickey  W Diagnosis of coeliac disease at open-access endoscopy. Scand J Gastroenterol. 1998;33612- 615
Link to Article
Volta  UMolinaro  NDe Franceschi  LFratangelo  DBianchi  FB IgA anti-endomysial antibodies on human umbilical cord tissue for celiac disease screening. Dig Dis Sci. 1995;401902- 1905
Link to Article
Whelan  AWilloughby  RWeir  D Human umbilical vein endothelial cells: a new easily available source of endomysial antigens. Eur J Gastroenterol Hepatol. 1996;8961- 966
Link to Article

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