While all the PPIs are effective for healing esophagitis, a more rapid relief of symptoms is seen with lansoprazole than with omeprazole, thereby enhancing patients' well-being. In studies73- 75 comparing lansoprazole and omeprazole in patients with GERD, lansoprazole provided more effective and rapid symptom relief. In a study73 of 229 patients at 9 Scandinavian hospitals, patients receiving lansoprazole, 30 mg once daily, experienced a significantly (P=.03) greater improvement in heartburn after 4 weeks compared with those receiving omeprazole. Furthermore, the median percentage of days on which patients required antacids during the first 4 weeks was lower in those receiving lansoprazole compared with those receiving omeprazole (11% vs 20%), although this difference was not statistically significant (P=.21). Similar findings were reported by Mee and colleagues,74 who studied 282 patients with GERD treated with lansoprazole, 30 mg once daily, and 283 patients treated with omeprazole, 20 mg once daily.74 At day 3 of treatment, a significant improvement in daytime symptoms of heartburn was reported by patients in the lansoprazole group compared with the omeprazole group (P=.05). In addition, at day 7, a significant (P=.03) improvement in daytime epigastric pain was reported by the lansoprazole group compared with those taking omeprazole. The findings of these 2 studies were further confirmed in a large US study75 of 1284 patients with endoscopically diagnosed erosive reflux esophagitis who were randomized to receive lansoprazole, 15 mg (n=218), lansoprazole, 30 mg (n=422), omeprazole, 20 mg (n=431), or placebo (n=213) once daily for 8 weeks. Patients receiving lansoprazole, 30 mg, experienced significantly less day and night heartburn than did patients receiving omeprazole, 20 mg, after the first day of therapy (P<.05). In addition, during the first week of treatment, those taking lansoprazole, 30 mg, experienced significantly less night and day heartburn compared with those taking omeprazole (P<.05). During all 8 weeks of therapy, patients treated with omeprazole experienced a significantly higher percentage of nights with heartburn compared with those treated with lansoprazole, 30 mg.