0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Vitamin D Supplementation and Fracture Risk

Heike A. Bischoff-Ferrari, MD, DrPH; Bess Dawson-Hughes, MD; Susan J. Whiting, PhD
Arch Intern Med. 2011;171(3):265. doi:10.1001/archinternmed.2010.531.
Text Size: A A A
Published online

Extract

In the July 12, 2010, issue of the Archives, Grey and Bolland1 incorrectly state that vitamin D does not reduce fracture risk, citing a single flawed meta-analysis2 in support and ignoring several others that reached the opposite conclusion (eg, Bischoff-Ferrari et al3,4). They dismiss as special pleading the fact that “advocates of vitamin D supplementation” point to inadequate vitamin D doses as an explanation for null effects. Serum 25-hydroxyvitamin D (25[OH]D) is defined by the Institute of Medicine as the indicator of vitamin D functional status. Trials that do not change serum 25 (OH)D level appreciably (or which are not shown to do so) do not and cannot test the hypothesis that vitamin D lowers disease risk. Most meta-analysts, seemingly unaware of the relevant biology, ignore this key point. Nor, in meta-analyses, is it appropriate to lump together studies using calcitriol or its analogs with studies using native cholecalciferol. Intracellular calcitriol concentrations needed for autocrine activity cannot be achieved by oral or intravenous calcitriol administration.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();