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Editor's Correspondence |

HIV Infection and Esophageal Cancer—Reply

Liron Pantanowitz, MD; Mark Bower, PhD, FRCP, FRCPath; Susan E. Krown, MD; Justin Stebbing, MD, MRCP, PhD
Arch Intern Med. 2010;170(10):916-917. doi:10.1001/archinternmed.2010.114.
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We thank Dr Rastegar for sharing this interesting case. Some cases of esophageal cancer in HIV-infected individuals may well be linked to HPV infection. We observed 1 HIV-infected individual who had an HPV-related condyloma of his esophagus (Figure), who was not included in our published series because we only included cases of invasive esophageal carcinoma. Others have reported similar individuals with HPV-related esophagitis.1 Recent published data support an association between high-risk HPV and esophageal carcinomas,2,3 although causation is not established and is controversial.

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Figure.

Histological analysis. A, Verrucoid condyloma of the esophageal squamous mucosa with human papillomavirus (HPV) effect (hematoxylin-eosin; original magnification ×100). B, In situ hybridization for high-risk HPV is positive within the nuclei of this biopsy specimen (hematoxylin-eosin, original magnification ×200).

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Correspondence

May 24, 2010
Liron Pantanowitz, MD; Mark Bower, PhD, FRCP, FRCPath; Susan E. Krown, MD; Justin Stebbing, MD, MRCP, PhD
Arch Intern Med. 2010;170(10):916-917. doi:10.1001/archinternmed.2010.114.
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