The general characteristics of the patient population are given in the Table. Fourteen hypoglycemic events (glucose levels, 40-59 mg/dL) were recorded in 12 patients (55%), 6 of whom were taking chronotrope/dromotrope (C/D)-negative agents (β-blockers [n = 5] and diltiazem [n = 1]). Eleven episodes occurred between 7 AM and 11 PM (daytime). No patient reported symptoms of hypoglycemia. Glucose and BP profiles of the 12 patients who had hypoglycemic recordings are shown in Figure 1. The median glucose value during hypoglycemia was 50 mg/dL (extreme values, 40-59 mg/dL), and the median duration of hypoglycemia was 25 minutes (extreme values, 10-120 minutes). Hypoglycemic events were followed 30 to 60 minutes later by a significant median 23% rise in systolic BP (SBP) (range, 3%-38%), from a mean (SD) of 125 (17) mm Hg to 154 (20) mm Hg (P = .003); a nonsignificant 8% rise in diastolic BP (P = .07); and no increase in heart rate (P = .30). During the control period, the median percentage variability of SBP was 3% (from −6% to 20% [P = .15] compared with the reference value). In 9 of these 12 patients (75%), the highest SBP recorded during the time a hypoglycemic event occurred (daytime or nighttime of the continuous BP recording) closely followed hypoglycemia. Individual SBP and heart rate values before and after hypoglycemic events are shown in Figure 2. The use of C/D-negative agents was associated with perfectly stable heart rate, whereas in the 6 patients free of C/D-negative agents, the heart rate tended to increase (Figure 2B) and was positively correlated with SBP elevation (P = .005). No correlation was observed between the increase in SBP and the patient's age, diabetes duration, renal function, and duration or severity of hypoglycemia. However, the ranges and duration of low glucose values were narrow.