0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Vitamin D Supplementation—Reply

Sara M. Pietras, MD; Michael F. Holick, PhD, MD
Arch Intern Med. 2010;170(6):572-573. doi:10.1001/archinternmed.2010.45.
Text Size: A A A
Published online

Extract

In reply

We appreciate and would like to respond to the comments submitted by Grey et al. Their first concern is a lack of randomized trial data reporting beneficial extraskeletal effects of vitamin D supplementation for an array of chronic diseases. We agree and do not recommend vitamin D supplementation to treat any of the diseases that they mention. However, the following 3 studies conducted within the past few years support the extraskeletal benefits of vitamin D supplementation. (1) The 4-year, randomized, double-blind, placebo-controlled trial by Lappe et al1 involving 1179 community-dwelling postmenopausal women in which calcium supplementation (consisting of either calcium citrate [1400 mg/d] or calcium carbonate [1500 mg/d]) was compared with calcium plus 1100 IU/d of cholecalciferol (vitamin D3). There was a significantly lower cancer rate in the calcium plus vitamin D group (relative risk [RR], 0.232; P < .005).1 (2) El-Hajj and colleagues2 treated 179 girls aged 10 to 17 years with the equivalent of either 200 IU or 2000 IU/d of vitamin D3 preparation over 1 year in a double-blind, placebo-controlled trial. They demonstrated a significant increase in lean muscle mass in both groups (P < .05). (3) Broe and colleagues3 treated nursing home residents with 800 IU/d of vitamin D2 and demonstrated a 72% lower adjusted-incidence rate ratio of falls, compared with those residents who received lower doses of vitamin D and for whom no benefit was seen.

Topics

vitamin d

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

March 22, 2010
Sara M. Pietras, MD; Michael F. Holick, PhD, MD
Arch Intern Med. 2010;170(6):572-573. doi:10.1001/archinternmed.2010.45.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();