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Articles | March 8, 2010

Error in Table 3 in: Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons

Arch Intern Med. 2010;170(5):477. doi:10.1001/archinternmed.2009.510.

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Error in Table 3. In the article titled “Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons” by Woolcott et al, published in the November 23, 2009, issue of the Archives (2009;169[21]:1952-1960), the second half of Table 3 was inadvertently omitted. The complete Table should have read as follows:

Table 3.

Pooled Bayesian Odds Ratios and Subgroup Sensitivity Analysis

Study CharacteristicAntihypertensivesDiureticsβ-BlockersSedatives/HypnoticsNo.^aOR (95% CI)No.^aOR (95% CI)No.^aOR (95% CI)No.^aOR (95% CI)No. of subjects497610145835444684No. taking drug1482237414321737All studies61.24 (1.01-1.50)91.07 (1.01-1.14)41.01 (0.86-1.17)71.47 (1.35-1.62)Population Community41.29 (1.00-1.65)31.08 (1.01-1.16)20.98 (0.79-1.18)^b51.50 (1.36-1.67) <35% Fallers31.34 (0.93-1.91)21.09 (1.00-1.17)10.94 (0.75-1.16)31.62 (1.44-1.84)^b ≥35% Fallers11.11 (0.78-1.58)^c11.04 (0.87-1.24)11.13 (0.72-1.70)21.22 (1.00-1.48)^b Long-term care10.80 (0.40-1.60)^c31.02 (0.84-1.25)21.18 (0.83-1.88)^b11.38 (1.14-1.74) Other11.19 (0.77-1.83)^c31.06 (0.82-1.38)00.43 (0.19-0.97)^b11.56 (1.19-2.05)Mean age of study subjects, y ≤7541.33 (1.03-1.68)41.11 (1.03-1.20)^b20.93 (0.71-1.18)41.54 (1.39-1.72) >7521.04 (0.79-1.38)^c50.96 (0.84-1.08)^b21.02 (0.81-1.28)31.37 (1.19-1.60)Medication/falls ascertainment Good11.19 (0.77-1.83)^c51.04 (0.89-1.23)10.87 (0.69-1.07)11.66 (1.25-2.22) Poor51.24 (0.97-1.54)41.09 (1.02-1.16)31.02 (0.84-1.21)61.43 (1.30-1.58)Study type Case-control21.09 (0.80-1.50)^c51.11 (0.94-1.32)10.87 (0.55-1.37)11.62 (1.31-2.00)^b Cohort31.34 (0.93-1.91)11.05 (0.97-1.15)01.00 (0.78-1.30)31.24 (1.05-1.45)^b Cross-sectional11.11 (0.78-1.58)^c31.11 (1.00-1.24)31.02 (0.79-1.24)31.56 (1.39-1.76)^bNeuroleptics/AntipsychoticsAntidepressantsBenzodiazepinesNarcoticsNSAIDsStudy CharacteristicNo.^aOR (95% CI)No.^aOR (95% CI)No.^aOR (95% CI)No.^aOR (95% CI)No.^aOR (95% CI)No. of subjects86172046932684128117828No. taking drug1303302150501314429All studies41.59 (1.37-1.83)91.68 (1.47-1.91)111.57 (1.43-1.72)40.96 (0.78-1.18)41.21 (1.01-1.44)Population Community21.76 (1.41-2.18)^b41.68 (1.39-2.03)61.55 (1.36-1.73)21.22 (0.79-1.66)11.12 (0.91-1.36) <35% Fallers11.75 (1.36-2.24)31.62 (1.22-2.03)51.53 (1.31-1.75)21.32 (0.87-1.80)11.08 (0.86-1.34) ≥35% Fallers11.78 (1.33-2.38)^c12.30 (1.41-3.69)11.58 (1.05-2.45)00.71 (0.27-1.82)01.34 (0.83-2.15) Long-term care11.55 (1.24-1.95)31.63 (1.35-1.98)21.43 (1.11-1.85)11.03 (0.61-1.54)11.41 (1.05-1.89) Other11.02 (0.65-1.61)^b21.70 (1.17-2.48)31.91 (1.43-2.55)10.94 (0.72-1.24)21.62 (0.21-12.60)^cMean age of study subjects, y ≤7511.72 (1.32-2.27)21.66 (1.33-2.04)51.55 (1.26-1.83)10.96 (0.73-1.27)21.26 (0.92-1.70) >7531.63 (1.27-2.03)71.79 (1.47-2.16)61.56 (1.39-1.77)31.24 (0.75-1.65)21.17 (0.95-1.43)Medication/falls ascertainment Good21.34 (1.05-1.68)^b41.68 (1.39-2.06)51.65 (1.39-1.98)20.81 (0.55-1.20)31.59 (1.11-2.24)^b Poor21.79 (1.46-2.17)^b51.64 (1.37-1.94)61.54 (1.36-1.72)21.11 (0.85-1.42)11.12 (0.93-1.35)^bStudy type Case-control11.23 (0.92-1.63)31.83 (1.42-2.35)32.18 (1.57-3.12)^b10.21 (0.10-0.45)^b,c21.62 (0.21-12.60)^c Cohort01.90 (1.35-2.67)21.67 (1.36-2.02)31.51 (1.29-1.75)^b11.49 (1.22-1.83)^b,c0NA Cross-sectional31.67 (1.38-2.00)41.57 (1.25-1.96)51.49 (1.24-1.73)^b21.18 (0.90-1.53)^b,c21.44 (0.49-4.03)^c

Abbreviations: CI, confidence interval; NA, not applicable; NSAIDs, nonsteroidal anti-inflammatory drugs; OR, odds ratio.

^aRefers to new study only.

^bGreater than 95% posterior probability that the difference between ORs is greater than 0.

^cAttained by random-effects inverse-variance model (frequentist) owing to unstable Bayesian model.

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