This study evaluated physical activity at age 60 years in relation to successful survival at 70 years and older in 13 535 women who participated in the Nurses' Health Study. Of these women, 1456 (10.8%) met the criteria of achieving successful survival, which was defined as being free of 11 major chronic diseases and having no physical, cognitive, and mental limitations. After controlling for a wide array of lifestyle and dietary covariates, total physical activity levels were associated with increased odds of achieving successful survival. Moreover, independent of vigorous physical activity, energy expenditure from walking, as well as walking pace, was associated with elevated odds of maintaining an overall health status in these women, with a strength similar to that for total physical activity. Findings from this study support the potential beneficial effects of physical activity on maintaining an optimal health status at older ages.