This meta-analysis estimated the effects of Internet- and computer-based smoking cessation programs from randomized controlled trials conducted on cigarette smokers. After searching 3 major databases including PubMed, EMBASE, and the Cochrane Review, Myung et al included a total of 22 randomized controlled trials in the final analysis. Overall, the results indicated that the interventions had a significant effect on smoking cessation (relative risk [RR], 1.44; 95% confidence interval [CI], 1.27-1.64). Similar findings were observed in 9 trials using an Internet-based intervention and in 13 trials using a computer-based intervention. Subgroup analyses revealed similar results for different levels of methodological rigor, stand-alone vs supplemental interventions, type of abstinence rates used, and follow-up period duration, but not for adolescent populations (RR, 1.08; 95% CI, 0.59-1.98). There is sufficient clinical evidence to support the use of Internet- and computer-based smoking cessation programs for adult smokers.