Jiao et al created a “healthy lifestyle” score, incorporating smoking, alcohol use, dietary quality, body weight, and physical activity, and examined it in relation to incident pancreatic cancer in a large US cohort. The higher score indicated a healthier lifestyle. Compared with the lowest score (0 points), the highest score (5 points) was associated with a 58% reduction in risk of developing pancreatic cancer (relative risk, 0.42; 95% confidence interval, 0.26-0.66). Not having the highest score explained 27% of pancreatic cancer cases in their population. These data suggest that one's risk of developing pancreatic cancer can be substantially reduced if one has a comprehensive behavioral profile reflecting factors including not smoking, alcohol use according to the US recommendation, a Mediterranean diet pattern, normal weight, and regular physical activity.