We thank Dhatariya for his comments on our study.1 Dhatariya mentions that there is no reason to include DHEA-S in the group of anabolic hormones. Although some studies in women partially support Dhatariya's arguments,2 there is enough evidence in the literature that DHEA-S exerts an anabolic effect on several tissues, which may be direct or mediated by the conversion to testosterone or by the stimulation of insulinlike growth factor 1 secretion.3 A number of observational studies show a significant positive association between serum DHEA-S levels and muscle mass and strength and a negative association with fat mass in both men and women.4,5 There is also evidence that DHEA-S is positively associated with bone mineral density (BMD) in the older population.6
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