For the NHANES dataset, sensitivity, specificity, positive predictive value, and negative predictive value of SCORED were estimated to be 95%, 65%, 20%, and 99%, respectively, with an AUC of 0.88. The application to ARIC/CHS provided sensitivity of 88% to 90%, specificity of 50% to 52%, positive predictive value of 13% to 14%, and negative predictive value of 98%, with an AUC of 0.78 to 0.80 (Table). In contrast, KEEP tended to place larger proportions of subjects into the high-risk category than SCORED (67%-77% vs 40%-53%), and the sensitivity for detecting CKD was 86% to 92%, with a specificity of 24% to 35%, positive predictive value of 3% to 12%, negative predictive value of 95% to 98%, and an AUC of 0.65 to 0.77. Results were robust under the different assumptions and approaches we adopted. Our comparisons give some indication about the expected performance of the 2 screening programs in real-world settings.