Editor's Correspondence |

The Relationship Between Testosterone and Mortality in Men: A Debatable Issue—Reply

Andre B. Araujo, PhD; Varant Kupelian, PhD; Stephanie T. Page, MD, PhD; David J. Handelsman, MB,BS, PhD; William J. Bremner, MD, PhD; John B. McKinlay, PhD
Arch Intern Med. 2008;168(3):330. doi:10.1001/archinternmed.2007.93.
Text Size: A A A
Published online


In reply

Paparrigopoulos et al seem to misunderstand the conclusion of our article,1 which is that sex steroids have virtually no relationship with mortality. As there is no relationship to be confounded, their subsequent comments regarding uncontrolled or residual confounding lack foundation. Furthermore, the many carefully selected covariates included in our analysis (age, body mass index, waist circumference, high-density lipoprotein cholesterol level, systolic blood pressure, race, alcohol consumption, calories expended in physical activity, smoking, self-assessed health, and self-reported heart disease, hypertension, and diabetes mellitus) represent a very comprehensive set of variables that could have confounded an association between testosterone and mortality. Additional factors affecting testosterone levels undoubtedly exist, but those mentioned by Paparrigopoulos et al were either controlled for (ie, alcohol consumption), based on scant data (ie, the impact of sleep duration on testosterone levels in 12 subjects2), or found to be unassociated with testosterone levels in the Massachusetts Male Aging Study (ie, depressive symptoms3).

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles