0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

The Relationship Between Testosterone and Mortality in Men: A Debatable Issue—Reply

Andre B. Araujo, PhD; Varant Kupelian, PhD; Stephanie T. Page, MD, PhD; David J. Handelsman, MB,BS, PhD; William J. Bremner, MD, PhD; John B. McKinlay, PhD
Arch Intern Med. 2008;168(3):330. doi:10.1001/archinternmed.2007.93.
Text Size: A A A
Published online

Extract

In reply

Paparrigopoulos et al seem to misunderstand the conclusion of our article,1 which is that sex steroids have virtually no relationship with mortality. As there is no relationship to be confounded, their subsequent comments regarding uncontrolled or residual confounding lack foundation. Furthermore, the many carefully selected covariates included in our analysis (age, body mass index, waist circumference, high-density lipoprotein cholesterol level, systolic blood pressure, race, alcohol consumption, calories expended in physical activity, smoking, self-assessed health, and self-reported heart disease, hypertension, and diabetes mellitus) represent a very comprehensive set of variables that could have confounded an association between testosterone and mortality. Additional factors affecting testosterone levels undoubtedly exist, but those mentioned by Paparrigopoulos et al were either controlled for (ie, alcohol consumption), based on scant data (ie, the impact of sleep duration on testosterone levels in 12 subjects2), or found to be unassociated with testosterone levels in the Massachusetts Male Aging Study (ie, depressive symptoms3).

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();