0
Editor's Correspondence |

Suicide: A Weighty Matter?

Beatrice A. Golomb, MD, PhD; Sarnoff A. Mednick, PhD; Leena Tenkanen, PhD
Arch Intern Med. 2007;167(17):1908. doi:10.1001/archinte.167.17.1908-a.
Text Size: A A A
Published online

Extract

We applaud the article by Mukamal and colleagues1 linking higher BMI to lower suicide risk. However, note that we previously reported the inverse connection of BMI to suicide.2 Indeed, we showed that this was part of a broader set of relationships.

Moreover, we had predicted this association. We theorized that markers of insulin resistance—including high BMI—might be linked to reduced risk of suicide. Why? Free fatty acid levels are elevated in insulin resistance. Free fatty acids compete with and displace tryptophan from binding to serum albumin, thus increasing the fraction of tryptophan that is free, and that can cross the blood-brain barrier where it is the substrate for the rate-limiting reaction in serotonin formation. Thus, we theorized that more insulin resistance may portend higher central serotonin levels and fewer suicides. Greater insulin sensitivity, analogously, may predict greater suicide risk.

Topics

suicide

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();