Author Contributions:Study concept and design: Clarke, Fletcher, and Collins. Acquisition of data: Clarke, Linksted, Sherliker, and Clark. Analysis and interpretation of data: Clarke, Emberson, Parish, Palmer, Shipley, Armitage, and Collins. Drafting of the manuscript: Clarke, Parish, and Shipley. Critical revision of the manuscript for important intellectual content: Emberson, Parish, Shipley, Sherliker, Clark, Armitage, Fletcher, and Collins. Statistical analysis: Clarke, Emberson, Parish, Shipley, and Collins. Obtained funding: Clarke, Fletcher, and Collins. Administrative, technical, and material support: Clarke, Parish, Linksted, Sherliker and Clark. Study supervision: Clarke, Parish, and Collins.