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Editor's Correspondence |

What If Chlorthalidone-Associated Hyperglycemia Develops?

Alan Silver, MD, MPH
Arch Intern Med. 2007;167(13):1434. doi:10.1001/archinte.167.13.1434-a.
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Barzilay et al1 present data and opinions supporting the contention that chlorthalidone-associated hyperglycemia is benign.2 What is the authors' opinion if it does develop? Does one ignore it, treat it and continue thiazide therapy, or stop the diuretic and change medications?

Barzilay  JIDavis  BRCutler  JA  et al. ALLHAT Collaborative Research Group, Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomised to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med 2006;166 (20) 2191- 2201
PubMed Link to Article[[XSLOpenURL/10.1001/archinte.166.20.2191]]
Phillips  RA New-onset diabetes mellitus less deadly than elevated blood pressure? following the evidence in the administration of thiazide diuretics. Arch Intern Med 2006;166 (20) 2174- 2176
PubMed Link to Article[[XSLOpenURL/10.1001/archinte.166.20.2174]]

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