0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Mend the Mind, but Mind the Bones!  Balancing Benefits and Potential Skeletal Risks of Serotonin Reuptake Inhibitors

Kenneth Saag, MD, MSc
Arch Intern Med. 2007;167(12):1231-1232. doi:10.1001/archinte.167.12.1231.
Text Size: A A A
Published online

Extract

Depression affects as many as 40% of adults older than 55 years,1 and major depressive disorder leads to substantial disability,2 with an estimated US societal cost of $83.1 billion in the year 2000.3 In the past 2 decades, second-generation antidepressants in the family of selective serotonin reuptake inhibitors (SSRIs) have vastly surpassed first-generation tricyclic antidepressants (TCAs) in the marketplace and now rank third among all drug classes in US prescription drug sales.4 The SSRIs have similar efficacy to TCAs in improving quality of life and decreasing mortality among depressed adults.4 Preference for SSRIs over TCAs has been driven by a lower risk of anticholinergic adverse effects and overdose lethality. Because of concerns about the arrhythmogenic potential of TCAs, there is a strong preference for SSRIs in older adults in whom depression commonly coincides with heart disease.5 Despite controversy about increased suicidality in children,6 SSRIs have continued to grow in popularity and have been largely devoid of other serious safety concerns, at least so far.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 13

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();