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Editor's Correspondence |

It Is Time We Ended the Myth of Insulin as an Atherogenic Hormone

Shirwan A. Mirza, MD
Arch Intern Med. 2007;167(8):858-859. doi:10.1001/archinte.167.8.858.
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When comparing the users and nonusers of insulin, lipid profile was not measured in either group. Lipid status in people with type 2 diabetes mellitus is very relevant in assessing atherogenesis as an underlying cause for hypertension, whether insulin is used or not. Furthermore, blood pressure readings were unavailable for all the insulin users at the onset of insulin therapy.

The degree of glycemic control (hemoglobin A1c) of either group was not mentioned. We do not know the baseline or follow-up levels of microalbuminuria (a strong marker of integrity of the renal vascular endothelium and an independent risk factor for atherosclerosis). Nor do we know the renal function. All these data, which are considered strong predictors of progression of atherosclerosis and subsequent development of hypertension, are lacking in this observational study.

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