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Editor's Correspondence |

Passive Transfer of Peanut Hypersensitivity by Fresh Frozen Plasma

Donald M. Arnold, MD, MSc, FRCPC; Morris A. Blajchman, MD, FRCPC; Julie DiTomasso, MLT, ART; Myron Kulczycki, MLT; Paul K. Keith, MD, MSc, FRCPC
Arch Intern Med. 2007;167(8):853-854. doi:10.1001/archinte.167.8.853.
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The passive transfer of clinically important nut allergy by the transfusion of fresh frozen plasma (FFP) has, to our knowledge, never before been documented. We report a case of peanut anaphylaxis in a nonatopic recipient of leukocyte-depleted FFP collected from a peanut-allergic donor.

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Link to Article[[XSLOpenURL/10.1001/jama.1919.02610390036012]]
Loveless  M Immunological studies of pollinosis, II: passive sensitization of man through transfusion. J Immunol 1941;3915- 34
Routledge  RCDe Kretser  DMWadsworth  LD Severe anaphylaxis due to passive sensitisation by donor blood. Br Med J 1976;1434
PubMed Link to Article[[XSLOpenURL/10.1136/bmj.1.6007.434]]
Phan  TGStrasser  SIKoorey  D  et al.  Passive transfer of nut allergy after liver transplantation. Arch Intern Med 2003;163237- 239
PubMed Link to Article[[XSLOpenURL/10.1001/archinte.163.2.237]]
Agosti  JMSprenger  JDLum  LG  et al.  Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation. N Engl J Med 1988;3191623- 1628
PubMed Link to Article[[XSLOpenURL/10.1056/NEJM198812223192502]]
Johansson  SGNopp  Avan Hage  M  et al.  Passive IgE-sensitization by blood transfusion. Allergy 2005;601192- 1199
PubMed Link to Article[[XSLOpenURL/10.1111/all.2005.60.issue-9]]
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Total IgE and peanut-specific IgE levels in a nonatopic recipient of fresh frozen plasma (FFP) collected from a peanut-allergic donor.

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