0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Risedronate for the Prevention of Hip Fractures: Concern About Validity of Trials

Jutta Martha Halbekath; Stefanie Schenk; Andreas von Maxen, MD; Gabriele Meyer, PhD; Ingrid Mühlhauser, MD
Arch Intern Med. 2007;167(5):513-515. doi:10.1001/archinte.167.5.513-b.
Text Size: A A A
Published online

Extract

With concern, we read the trials conducted by Sato and colleagues comparing risedronate sodium with placebo in male patients with stroke1 and female patients with Alzheimer disease (AD).2

Both trials were conducted in a single center. Yet, patients (500 women with AD and 280 men with stroke) were recruited in only 3 months: the patients with AD in March and April 2003 and the patients with stroke in April and May 2003. Related to a third single-center trial with risedronate in 374 female patients with stroke at the same hospital that was published by the group in 2005,3 a correspondence letter4 expressed concern about the high frequency of recruitment, which was performed in only 4 months (between April and July 2003).3 In their reply, Sato and colleagues5 stated that their hospital is a specialized center for stroke and that they treat about 2800 patients with stroke per year. Even if these circumstances are taken into account, recruiting 280 male patients with stroke who meet all eligibility criteria in a single center in only 2 months appears implausible. This applies to an even greater extent to the 500 female patients with AD. Of note, Sato et al1,2 stated that only 1 physician (ie, Sato himself) did all AD diagnoses as well as the follow-up assessments of all 780 patients every 4 weeks.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

The Rational Clinical Examination
Clinical Scenario

brightcove.createExperiences();