McMillan-Price and colleagues1 are to be congratulated for performing a large study to examine the impact of low-glycemic-load weight loss diets. However, the conclusions do not tally with the data in the article. All diets caused fat loss, and there was no significant difference between them. The post hoc analysis of weight loss in women is not justified without first showing a significant interaction between sex and fat loss. Although the high-carbohydrate, low–glycemic index (GI) diet lowered low-density lipoprotein cholesterol (LDL-C) levels the most, the high-protein, low-GI diet lowered the high-density lipoprotein cholesterol (HDL-C) ratio the most. Thus, the conclusion that the high-carbohydrate, low-GI diet is best for lowering heart disease risk is not justified on the data presented. The results of the study in relation to LDL-C are very unusual, since striking reductions in saturated fat were reported with all the diets but elevations in LDL-C levels were observed in 2 of the diets. The fact that HDL-C level rose despite the reported reductions in total dietary fat in all the diets casts doubt on the food records. The low level of energy reported in the food records does not accord with the relatively low amount of weight lost. Perhaps the diets are best described as recommended patterns rather than controlled diets.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
The Rational Clinical Examination
About 16% of general medical patients report that they have palpitations.1 Within...
All results at
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.