0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

Methadone-Induced Long QT Syndrome vs Methadone-Induced Torsades de Pointes

Dan Justo, MD
Arch Intern Med. 2006;166(20):2288. doi:10.1001/archinte.166.20.2288-b.
Text Size: A A A
Published online

Extract

Ehret et al1 pointed out the high frequency of methadone-induced long QT syndrome (LQTS) among hospitalized drug users and its risk factors. Interestingly, in their study only 4 of 50 patients with LQTS induced by methadone hydrochloride also had torsades de pointes (TdP).1 Moreover, although methadone use might have been associated with LQTS in outpatients as well as in inpatients,1,2 and although millions of patients have been using methadone since the 1960s, only 43 patients with methadone-induced TdP were reported to the US Food and Drug Administration up to October 2002.3 Therefore, it is possible that methadone, just like amiodarone,4 might be normally associated with LQTS and rarely with TdP. If this is the case, preventing methadone-induced LQTS and preventing methadone-induced TdP is not the same. In fact, in the study by Ehret et al,1 2 patients had TdP, although their corrected QT (QTc) intervals were within normal range.1

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();