Elkind et al determined levels of high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in 467 patients with incident stroke from a population-based study. Level of hs-CRP, but not Lp-PLA2 level, was associated with stroke severity. After adjusting for demographic and medical risk factors, Lp-PLA2 level, but not hs-CRP level, was associated with risk of recurrent stroke. Compared with the lowest quartile of Lp-PLA2 level, those in the highest had an increased risk of recurrent stroke (adjusted hazard ratio, 2.08). Those in the highest quartile of hs-CRP level had approximately double the mortality of those in the lowest quartile. Level of Lp-PLA2 may be a stronger predictor of recurrent stroke risk than hs-CRP level, while hs-CRP level appears to be associated with mortality after stroke.