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Editor's Correspondence |

Acquired Hydrocephalus Caused by a Variant Lymphocytic Choriomeningitis Virus

Remi N. Charrel, MD, PhD; Karine Retornaz, MD; Sébastien Emonet, MSc; Guilhem Noel, MD; Kathia Chaumoitre, MD; Philippe Minodier, MD; Nadine Girard, MD, PhD; Jean-Marc Garnier, MD, PhD; Xavier de Lamballerie, MD, PhD
Arch Intern Med. 2006;166(18):2044-2046. doi:10.1001/archinte.166.18.2044.
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Lymphocytic choriomeningitis (LCM) virus is a rodent-associated zoonotic arenavirus that causes asymptomatic or mild illness and aseptic meningitis in humans.1 Recently, attention has been drawn to LCM after a cluster of fatal cases in transplantation patients.2 Hydrocephalus is common in congenital LCM but uncommon in acquired infections. We present herein a case of acquired hydrocephalus caused by a variant LCM virus and the genetic identification of the zoonotic source.

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Computed tomographic scan and magnetic resonance examination of the patient with hydrocephalus. A, Computed tomographic scan performed without contrast injection in an emergency situation, with major hydrocephalus and hyperhydration of the periventricular white matter manifesting as low-density areas. Magnetic resonance examination: B, coronal T2-weighted image; C, coronal fluid-attenuated inversion recovery (FLAIR) image; and D, contrast-enhanced axial T1-weighted image. The arrows show enlargement of the subdural spaces overlying the cerebral surface (B), with thickened dura mater that appears bright on FLAIR image (C), and enhanced dura mater after gadolinium injection (D).

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