Regardless of which precursor protein causes disease, the deposits are virtually indistinguishable with light microscopy. The amorphous proteinacous substance stains pink with Congo red staining, with apple-green birefringence under polarizing light microscopy. The spectrum of organ involvement can include the kidneys, heart, blood vessels, central and peripheral nervous systems, liver, intestines, lungs, eyes, skin, and bones.3 Amyloid deposition in the heart is a devastating and progressive process that leads to congestive heart failure, angina, and arrhythmias. For patients with amyloidosis, infiltration of the heart confers the worst prognosis. In this systematic review, we discuss the clinical features of cardiac amyloidosis, present a diagnostic approach, and describe potential therapies.