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Editor's Correspondence |

Infliximab and Human Immunodeficiency Virus Infection: Viral Load Reduction and CD4+ T-Cell Loss Related to Apoptosis

Jérôme Filippi, MD; Pierre-Marie Roger, MD, PhD; Stéphane M. Schneider, MD; Jacques Durant, MD; Jean-Philippe Breittmayer, PhD; Sylvia Benzaken, MD; Alain Bernard, MD, PhD; Pierre Dellamonica, MD, PhD; Xavier Hébuterne, MD, PhD; Groupe d’Etude Niçois Polyvalent en Infectiologie(GENPI)
Arch Intern Med. 2006;166(16):1783-1784. doi:10.1001/archinte.166.16.1783.
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Infliximab is a monoclonal anti–tumor necrosis factor (TNF)-α antibody indicated in steroid-resistant and/or fistulizing Crohn disease (CD). Reactivation of chronic viral hepatitis as well as opportunistic infections have been reported as adverse effects,1,2 but the impact of such drugs on patients' virological and immunological status remains unknown.3

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Human immunodeficiency virus viral load and CD4+ T-cell count after infliximab therapy. A, Kinetics of both viral load and CD4+ T-cell count are indicated from 15 months before infliximab infusion, at the end of antiretroviral treatment, and 12 months after the treatment (x-axis), the latter showing an association with a dramatic decrease of both biological parameters over the period of anti–tumor necrosis factor treatment. Arrows indicate treatment infusions. B, We used a 4-staining cytofluorometric technique: T-cell subsets were recognized among CD45+ cells, using CD3–fluorescein isothiocyanate staining. Percentage of positive cells are indicated for each quadrant. C, A computer-assisted DNA histogram for CD4+ T cells (gate 1) and CD8 T cells (gate 2) separated by immunofluorescence analysis. Apoptotic cells manifested as a peak displaying reduced fluorescence. D, Kinetics of CD86 expression on monocytes in the patient and 12 healthy controls (triangles). APC indicates antigen-presenting cell; MIF, mean intensity fluorescence; PE, phycoerythrin.

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