In an effort to encourage research on the topic, a special issue of the ARCHIVES will be devoted to papers on the topic of preventive interventions. Specifically, we are interested in receiving papers focused on the efficacy or effectiveness of interventions. While we will primarily concentrate on randomized controlled trials that assess efficacy, we will also consider papers that employ observational methods of investigation or economic analyses that reasonably estimate theoretical cost-effectiveness of interventions. All kinds of preventive interventions are welcomed—those in the community, in medical offices, in clinics, and in hospitals or other advanced-care settings. However, priority for this theme issue will be given to those papers that are applicable to the practicing internist.