Editor's Correspondence |

The Safety and Efficacy of Dose-Sparing Intradermal Administration of Influenza Vaccine in Human Immunodeficiency Virus–Positive Patients

Homayoon Khanlou, MD; Susan Sanchez, MD; Michele Babaie, MD; Catherine Chien, MD; Gerald Hamwi, MD; Juan-Carlos Ricaurte, MD; Tomiko Stein, MD; Laveeza Bhatti, MD; Paul Denouden, MD; Charles Farthing, MD
Arch Intern Med. 2006;166(13):1417. doi:10.1001/archinte.166.13.1417.
Text Size: A A A
Published online


The United States has experienced a shortage of inactivated influenza vaccine during the last 3 influenza seasons, leaving many patients at risk.1 The possibility of extending existing vaccine supplies by using an alternative intradermal route of vaccination that requires smaller doses as a means of “stretching” available doses of influenza vaccine could have important public health implications. This would enable, despite the current limited supply of the vaccine, vaccination of many more patients than would otherwise be possible. During the influenza season of 2004-2005 and facing a shortage of influenza vaccine in our clinics, we consulted with our central institutional review board and decided to study this potential alternative. The AIDS Healthcare Foundation operates 4 major and 5 satellite clinics throughout the Los Angeles (Calif) metropolitan area. Our objective was to compare the immunogenicity and safety of the candidate vaccine administered intradermally at a reduced dose (0.1 mL) with the reference influenza vaccine administered intramuscularly at the standard dose (0.5 mL). We compared antibody responses to reduced intradermal dosing of the influenza vaccine with standard intramuscular dosing in human immunodeficiency virus–positive patients. The patients were randomized on a 2:1 basis to arm A (receiving 0.1 mL of influenza vaccine via intradermal injection) or arm B (receiving 0.5 mL of influenza vaccine via intramuscular injection).

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 17

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles