The article by Nash1 titled “The Case for Medical Treatment in Chronic Stable Coronary Artery Disease” in the December 12/26, 2005 issue of the ARCHIVES cited a mechanism for ranolazine that is not consistent with current data regarding the antianginal effects of ranolazine therapy.
Several mechanisms have been previously proposed.2- 3 Although ranolazine was shown to have partial fatty acid oxidase inhibitor activity in preclinical investigations,2- 3 it occurs at concentrations far above those achieved in recent clinical trials demonstrating therapeutic benefit and is probably not the primary mechanism for clinical efficacy.3- 5
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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