Acute and chronic inflammatory processes and concomitant disturbances in cell adhesion characterize the pathogenesis of sickle cell disease. To investigate these processes further, we analyzed serum levels of highly sensitive C-reactive protein (CRP), vascular cell adhesion molecule-1 (VCAM-1), intracellular cell adhesion molecule-1 (ICAM-1), and interleukin (IL)-1β, IL-2, IL-6, IL-8, and IL-12 in a homogenous cohort of individuals with double heterozygous sickle cell/β-thalassemia. We found that steady-state serum levels of CRP and VCAM-1 demonstrated statistically significant correlations with the clinical severity index in this cohort (P = .01), while other markers showed no associations. Although the mechanisms underlying observed associations between serum CRP and VCAM-1 levels and adverse outcomes have yet to be elucidated, their measurement during the course of sickle cell/β-thalassemia may guide and predict disease evolution and outcome. Furthermore, therapies that reduce these levels in the steady state of sickle cell disease may be clinically useful.
Correlation between C-reactive protein (CRP) levels and the sickle cell severity index in 35 patients with sickle cell/β-thalassemia. Significant correlations between CRP level and individual components of the sickle cell severity index were not observed (cutoff points were not used).
Correlation between serum vascular cell adhesion molecule-1 (VCAM-1) levels and the sickle cell severity index.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 11
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.