Subclinical disease remained a significant predictor in the multivariable Cox proportional hazards models of the risk of CHD, as shown in Table 5, modeled separately for men and women. Age, presence of diabetes mellitus, measurements of inflammation, renal insufficiency, CRP or white blood cell count, and subclinical disease were the primary determinants of the risk of CHD. There was only a weak and inconsistent relationship between subclinical disease and level of lipids. For women, the HR of subclinical disease for CHD was only slightly reduced by the inclusion of these risk factors, from 1.61 (CI,1.30-2.01) (Table 1) to 1.49 (95% CI, 1.21-1.84) and for men, from 1.87 (95% CI, 1.48-2.35) to 1.64 (95% CI,1.30-2.06). Renal insufficiency, defined as a creatinine level of 1.3 mg/dL (99.1 μmol/L) or higher for women, was a strong risk factor for CHD (Table 5). The prevalence of a creatinine level of 1.3 mg/dL (99.1 μmol/L) or higher for women is very low, however: 5.8% for those with subclinical disease and incident CHD (Table 4). For other end points, risk factor–adjusted HRs from Cox models for women were 1.40 (95% CI, 1.17-1.66) for total mortality, 1.71 (95% CI, 1.23-2.38) for MI, and 1.65 (95% CI, 1.26-2.18) for stroke; for men, HRs were 1.73 (95% CI, 1.39-2.14) for total mortality, 1.35 (95% CI, 0.98-1.86) for MI, and 1.38 (95% CI, 0.95-2.01) for stroke.