0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Interrupted Time Series Analysis of the Effect of Rescheduling Alprazolam in Australia Taking Control of Prescription Drug Use

Andrea L. Schaffer, MSc, MBiostat1; Nicholas A. Buckley, MD2; Rose Cairns, PhD3; Sallie-Anne Pearson, PhD1
[+] Author Affiliations
1Centre for Big Data Research in Health, University of New South Wales, Australia
2Pharmacology, University of Sydney, Australia
3New South Wales Poisons Information Centre, Children’s Hospital at Westmead, Australia
JAMA Intern Med. 2016;176(8):1223-1225. doi:10.1001/jamainternmed.2016.2992.
Text Size: A A A
Published online

Extract

This study evaluates the effect of rescheduling alprazolam on benzodiazepine prescribing, dispensing, and intentional poisonings.

Alprazolam is significantly more toxic, has no additional therapeutic benefit, and is increasingly misused compared with other benzodiazepines.13 Due to concerns about the increasing use of alprazolam, in February 2014, the Australian Therapeutic Goods Administration selectively rescheduled alprazolam from Schedule 4 (Prescription Only Medicine) of the Poisons Standard to Schedule 8 (Controlled Drug), equivalent to Schedule II in the United States. This change resulted in increased restrictions for the prescribing and dispensing of alprazolam.4 The objective of this study was to determine the effect of rescheduling alprazolam on benzodiazepine prescribing, dispensing, and intentional poisonings.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure.
Monthly Time Series of Alprazolam Prescriptions per 100 000 Population, Dispensings, and Calls to Poisons Information Centre

The rescheduling was announced on June 28, 2013, whereas the rescheduling took effect on February 1, 2014.

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

381 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
Jobs
JAMAevidence.com

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis

brightcove.createExperiences();