We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Comment & Response | Less Is More

Estimating Vitamin D Status and the Choice of Supplementation Dose

Cédric Annweiler, MD, PhD1; Guillaume Duval, MD, MS1; Cyrille P. Launay, MD, PhD2
[+] Author Affiliations
1Division of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, UPRES EA 4638, University of Angers, UNAM, Angers, France
2Service of Geriatric Medicine and Geriatric Rehabilitation, Department of Medicine, Lausanne University Hospital, Switzerland
JAMA Intern Med. 2016;176(6):865. doi:10.1001/jamainternmed.2016.1612.
Text Size: A A A
Published online


To the Editor In a recent issue of JAMA Internal Medicine, Bischoff-Ferrari and colleagues1 reported the results of an interesting randomized clinical trial testing the efficiency of physiological (equivalence, 800 IU/d) and supraphysiological doses (equivalence, 2000 IU/d or 800 IU/d plus calcifediol 300 μg/mo) of vitamin D supplements in lowering the risk of functional decline. The authors found that older participants in the higher-dose vitamin D groups experienced the greater incidence of falls,1 a result already described with mega doses of vitamin D supplementation2 but in contradiction with the well-recognized antifall effect of physiological doses.3


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





June 1, 2016
Heike A. Bischoff-Ferrari, MD, DrPH; E. John Orav, PhD; Bess Dawson-Hughes, MD
1Department of Geriatrics and Aging Research, University Hospital Zurich, Switzerland2Centre on Aging and Mobility, University of Zurich, Switzerland
3Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
4USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
JAMA Intern Med. 2016;176(6):865-866. doi:10.1001/jamainternmed.2016.1629.
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...