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Comment & Response | Less Is More

Estimating Vitamin D Status and the Choice of Supplementation Dose

Cédric Annweiler, MD, PhD1; Guillaume Duval, MD, MS1; Cyrille P. Launay, MD, PhD2
[+] Author Affiliations
1Division of Geriatric Medicine, Department of Neuroscience, Angers University Hospital, UPRES EA 4638, University of Angers, UNAM, Angers, France
2Service of Geriatric Medicine and Geriatric Rehabilitation, Department of Medicine, Lausanne University Hospital, Switzerland
JAMA Intern Med. 2016;176(6):865. doi:10.1001/jamainternmed.2016.1612.
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To the Editor In a recent issue of JAMA Internal Medicine, Bischoff-Ferrari and colleagues1 reported the results of an interesting randomized clinical trial testing the efficiency of physiological (equivalence, 800 IU/d) and supraphysiological doses (equivalence, 2000 IU/d or 800 IU/d plus calcifediol 300 μg/mo) of vitamin D supplements in lowering the risk of functional decline. The authors found that older participants in the higher-dose vitamin D groups experienced the greater incidence of falls,1 a result already described with mega doses of vitamin D supplementation2 but in contradiction with the well-recognized antifall effect of physiological doses.3

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June 1, 2016
Heike A. Bischoff-Ferrari, MD, DrPH; E. John Orav, PhD; Bess Dawson-Hughes, MD
1Department of Geriatrics and Aging Research, University Hospital Zurich, Switzerland2Centre on Aging and Mobility, University of Zurich, Switzerland
3Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
4USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts
JAMA Intern Med. 2016;176(6):865-866. doi:10.1001/jamainternmed.2016.1629.
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