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Mixed Diagnoses and Mixed Messages

Jeffrey A. Linder, MD, MPH1; Mark W. Friedberg, MD, MPP1
[+] Author Affiliations
1Division of General Internal Medicine and Primary Care, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Intern Med. 2016;176(5):718-719. doi:10.1001/jamainternmed.2016.1284.
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To the Editor The pragmatic, randomized clinical trial of delayed antibiotic prescribing strategies reported by de la Poza Abad and colleagues1 combined antibiotic-inappropriate diagnoses (acute bronchitis) and diagnoses for which antibiotics might be appropriate (rhinosinusitis, pharyngitis). Combining and randomizing patients with diagnoses that should and should not receive antibiotics limits the interpretability and applicability to clinical practice of the trial.


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May 1, 2016
Pablo Alonso-Coello, MD, PhD; Carl Llor, MD, PhD; Mariam de la Poza Abad, MD
1Iberoamerican Cochrane Center, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain2CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
3Via Roma Primary Care Center, Barcelona, Spain
4Doctor Carles Ribas Primary Care Center, Barcelona, Spain
JAMA Intern Med. 2016;176(5):719. doi:10.1001/jamainternmed.2016.1287.
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