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Comment & Response |

Neuraminidase Inhibitors and Influenza Infection

Michael Osthoff, MD1; Stefan Erb, MD1
[+] Author Affiliations
1Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland
JAMA Intern Med. 2016;176(3):415. doi:10.1001/jamainternmed.2016.0013.
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To the Editor Louie and Lampiris1 summarize current evidence for the treatment of influenza infection with neuraminidase inhibitors. At first, they discuss the persistent uncertainty and inadequate evidence regarding the effectiveness of neuraminidase inhibitors in outpatients at risk for severe disease and in hospitalized patients. But they then come full circle and recommend prompt treatment of these patients based on data from observational studies and ethical concerns that would preclude randomized clinical trials.

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March 1, 2016
Peter Doshi, PhD; Tom Jefferson, MD, MRCGP, FFPHM
1Department of Pharmaceutical Health Services Research, University of Maryland School of Pharmacy, Baltimore, Maryland
2Centre for Evidence-Based Medicine, Oxford University, Oxford, United Kingdom
JAMA Intern Med. 2016;176(3):415-416. doi:10.1001/jamainternmed.2016.0016.
March 1, 2016
Janice K. Louie, MD, MPH; Harry Lampiris, MD
1Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco
1Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco2San Francisco VA Health Care System, San Francisco, California
JAMA Intern Med. 2016;176(3):416-417. doi:10.1001/jamainternmed.2016.0050.
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