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Comment & Response |

Discontinuation of Antihypertensive Treatment in Elderly Patients and Cognitive Function

Konstantinos Imprialos, MD, PhD1; Chrysoula Boutari, MD, PhD1; Michael Doumas, MD, PhD2
[+] Author Affiliations
1Second Propedeutic Department of Internal Medicine, Aristotle University, Thessaloniki, Greece
2Department of Medicine, George Washington University, Washington, DC
JAMA Intern Med. 2016;176(3):409. doi:10.1001/jamainternmed.2015.8342.
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To the Editor The DANTE study1 provided data of high clinical significance considering that it is the very first study evaluating the effect of antihypertensive treatment discontinuation on cognitive function in elderly patients. As mentioned by Moonen et al, the termination of the treatment had no beneficial results on the cognitive, psychological, and general function, even in subgroup analysis based on several factors. We would be obliged to the authors if they performed an additional analysis according to baseline pulse pressure levels and estimated glomerular filtration rate.

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March 1, 2016
Jessica C. Foster-Dingley, MSc; Justine E. F. Moonen, MD; Roos C. van der Mast, MD, PhD
1Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
1Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands2Department of Psychiatry, CAPRI-University of Antwerp, Antwerp, Belgium
JAMA Intern Med. 2016;176(3):409-410. doi:10.1001/jamainternmed.2015.8345.
October 1, 2015
Justine E. F. Moonen, MD; Jessica C. Foster-Dingley, MSc; Wouter de Ruijter, MD, PhD; Jeroen van der Grond, PhD; Anne Suzanne Bertens, MD; Mark A. van Buchem, MD, PhD; Jacobijn Gussekloo, MD, PhD; Huub A. Middelkoop, PhD; Marieke J. H. Wermer, MD, PhD; Rudi G. J. Westendorp, MD, PhD; Anton J. M. de Craen, PhD; Roos C. van der Mast, MD, PhD
1Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands
2Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands
3Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
3Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands4Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
5Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands6Section of Health, Medical and Neuropsychology, Department of Psychology, Leiden University, Leiden, the Netherlands
5Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands
7Leyden Academy on Vitality and Aging, Leiden University Medical Center, Leiden, the Netherlands8Center for Healthy Aging, Department of Public Health, University of Copenhagen, Cophenhagen, Denmark
4Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
1Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands9Department of Psychiatry, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Antwerp, Belgium
JAMA Intern Med. 2015;175(10):1622-1630. doi:10.1001/jamainternmed.2015.4103.
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