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Comment & Response |

Proposed Guidelines for Future Vitamin D Studies

William B. Grant, PhD1; Luca Mascitelli, MD2; Mark R. Goldstein, MD, FACP3
[+] Author Affiliations
1Sunlight, Nutrition, and Health Research Center, San Francisco, California
2Comando Brigata Alpina “Julia,” Multinational Land Force, Medical Service, Udine, Italy
3NCH Physician Group, Naples, Florida
JAMA Intern Med. 2016;176(2):279-280. doi:10.1001/jamainternmed.2015.7968.
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To the Editor The trial by Hansen and colleagues1 was designed to study the effects of vitamin D supplementation on calcium absorption, bone mineral density (BMD), muscle function, and muscle mass. Serum 25-hydroxyvitamin D (25[OH]D) concentrations increased from 21 to 27 ng/mL (to convert to nanomoles per liter, multiply by 2.496) for low-dose vitamin D (LDD) and 42 ng/mL for high-dose vitamin D (HDD) by the end of the year-long trial. Total-hip BMD increased by 0.4% for LDD and 0.7% for HDD. Femoral neck BMD decreased by 0.1% for LDD and increased by 0.5% for HDD. The 95% CI ranged from 1.0% to 2.5%. Since only small effects were found, the results of this trial were interpreted as implying that 25(OH)D concentrations of 20 ng/mL are adequate.

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February 1, 2016
Ayse Nur Tufan, MD; Fatih Tufan, MD
1Division of Rheumatology, Department of Internal Medicine, Uludag University, Bursa, Turkey
2Division of Geriatrics, Department of Internal Medicine, Istanbul University, Istanbul, Turkey
JAMA Intern Med. 2016;176(2):280. doi:10.1001/jamainternmed.2015.7971.
February 1, 2016
Rudruidee Karnchanasorn, MD; Horng-Yih Ou, MD, PhD; Ken C. Chiu, MD
1Division of Endocrinology, Department of Medicine, University of Kansas Medical Center, Kansas City
2Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
3Department of Clinical Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, Duarte, California
JAMA Intern Med. 2016;176(2):280-281. doi:10.1001/jamainternmed.2015.7974.
February 1, 2016
Karen E. Hansen, MD, MS; Michael G. Johnson, MS
1Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison
JAMA Intern Med. 2016;176(2):281-282. doi:10.1001/jamainternmed.2015.7983.
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