We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Invited Commentary |

Long-term Marijuana Use and Cognitive Impairment in Middle Age

Wayne Hall, PhD1,2; Michael Lynskey, PhD2
[+] Author Affiliations
1Centre for Youth Substance Abuse Research, The University of Queensland, Queensland, Australia
2National Addiction Centre, Kings College London, United Kingdom
JAMA Intern Med. 2016;176(3):362-363. doi:10.1001/jamainternmed.2015.7850.
Text Size: A A A
Published online


During the last 20 years, there have been substantial changes in the legal status and public perception of marijuana in the United States. Decriminalization, medical dispensaries with marijuana for those with a physician’s note, and legalization of marijuana in several states have resulted in increased availability and more relaxed views toward marijuana use. However, to our knowledge, relatively little research has been done on the risks of long-term marijuana use.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment
Verbal deficits: cause or effect of cannabis abuse?
Posted on February 2, 2016
David L. Keller, MD
Conflict of Interest: None Declared
Multiple studies have now demonstrated an association between neurological degeneration and chronic cannabis use during adolescence and young adulthood. Given that mature brains share mechanisms of repair and learning with young brains, to the extent that these abilities are retained, there is little to suggest that the effects of cannabis will be found to be any kinder to mature brains. Still, legalization of cannabis can be justified by the following arguments:
1) Legalization will dissipate the counter-cultural allure of the officially banned weed.
2) Legalization will neutralize arguments that corporate puppet-masters (or whomever) are conspiring to repress the users of this weed
3) There are worse things than verbal deficits. I can't think of any off-hand, but I don't want to impose my values on the less communicative.
4) While cannabis is clearly harmful, its harms occur slowly and over sufficient time for the abuser to give it up before the damage is too far gone (usually).
5) Full legalization will remove these debates from pages better devoted to the advancement of medical science.

Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles