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Research Letter |

Recurrence and Mortality in Young Women With Myocardial Infarction or Ischemic Stroke Long-term Follow-up of the Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) Study

Alberto Maino, MD1,2; Bob Siegerink, PhD1,3; Ale Algra, MD, PhD1,4,5; Flora Peyvandi, MD, PhD2; Frits R. Rosendaal, MD, PhD1,2,6
[+] Author Affiliations
1Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
2Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy
3Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin, Berlin, Germany
4Brain Center Rudolph Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, the Netherlands
5Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
6Department of Thrombosis and Haemostasis, Leiden University Medical Center, Leiden, the Netherlands
JAMA Intern Med. 2016;176(1):134-136. doi:10.1001/jamainternmed.2015.6523.
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This Research Letter reports the long-term mortality and subtype-specific morbidity in young women surviving myocardial infarction or ischemic stroke.

Rates of death in the acute phase of cardiovascular events have decreased, but disease burden remains high in the increasing number of survivors.1 This finding is particularly important for those affected at a young age.2 Nevertheless, little information is available on the long-term outcome of young patients who survived a cardiovascular event, especially women. Single disease cohorts have suggested that the risk of cardiovascular disease is driven by recurrence of the index event, but, to our knowledge, this has never been investigated in a single study with multiple index groups. We determined the long-term mortality and subtype-specific morbidity in young women surviving myocardial infarction (MI) or ischemic stroke (IS) compared with a control group.

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Kaplan-Meier Curves for Overall Mortality

IS indicates ischemic stroke; MI, myocardial infarction.

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