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Comment & Response | Less Is More

Selecting the Optimal Design for Drug Discontinuation Trials in a Setting of Advanced, Life-Limiting Illness

Eric C. T. Geijteman, MD1,2; Henning Tiemeier, MD, PhD3; Teun van Gelder, MD, PhD4
[+] Author Affiliations
1Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam
2Department of Public Health, Erasmus University Medical Center, Rotterdam
3Department of Epidemiology, Erasmus University Medical Center, Rotterdam
4Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam
JAMA Intern Med. 2015;175(10):1724-1725. doi:10.1001/jamainternmed.2015.3997.
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To the Editor We read with great interest the article by Kutner et al.1 The authors showed that discontinuing statins in patients with a limited life expectancy is safe and may lead to improved quality of life. The accompanied editorial2 states that the statin trial provides a starting point for deprescribing trials in frail patients with advanced illness.

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October 1, 2015
Purav Mody, MD; Oanh Kieu Nguyen, MD, MAS
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas2Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, Texas
JAMA Intern Med. 2015;175(10):1725. doi:10.1001/jamainternmed.2015.4000.
October 1, 2015
Jean S. Kutner, MD, MSPH; Christine S. Ritchie, MD, MSPH; Amy P. Abernethy, MD, PhD
1Department of Medicine, University of Colorado School of Medicine, Aurora
2San Francisco Veterans Affairs Medical Center, Center for Research on Aging at the Jewish Home of San Francisco, San Francisco, California3Division of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco
4Center for Learning Health Care, Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina
JAMA Intern Med. 2015;175(10):1725. doi:10.1001/jamainternmed.2015.4003.
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