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Comment & Response |

Cervical Cancer Screening by Human Papillomavirus Testing Followed by Cytology Triage

Paolo Giorgi-Rossi, PhD1,2; Marc Arbyn, MD3; Chris J. L. M. Meijer, MD4
[+] Author Affiliations
1Interinstitutional Epidemiology Unit, AUSL (Azienda Unità Sanitaria Locale) Reggio Emilia, Reggio Emilia, Italy
2Arcispedale S. Maria Nuova, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Reggio Emilia, Italy
3Unit of Cancer Epidemiology and Belgian Cancer Centre, Scientific Institute of Public Health, Brussels, Belgium
4Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, the Netherlands
JAMA Intern Med. 2015;175(6):1068. doi:10.1001/jamainternmed.2015.0592.
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To the Editor In her Viewpoint about human papillomavirus (HPV) testing for primary cervical cancer screening, Feldman1 discusses the possible increase in costs, in particular for colposcopies. However, in the European trials, HPV-based screening followed by cytology triage of HPV-positive women was compared with screening based on Papanicolaou testing.2 The biopsy rate was so similar and with such narrow confidence intervals (relative risk, 1.02; 95% CI, 0.97-1.07) that there was strong evidence of a lack of difference between the approaches.2


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June 1, 2015
Sarah Feldman, MD, MPH
1Department of Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Intern Med. 2015;175(6):1068-1069. doi:10.1001/jamainternmed.2015.0596.
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