Accepted for Publication: March 2, 2015.
Published Online: April 27, 2015. doi:10.1001/jamainternmed.2015.1180.
Study concept and design: van Nimwegen, Schaapveld, Aleman, van Leeuwen.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: van Nimwegen, Schaapveld.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: van Nimwegen, Schaapveld, van Leeuwen.
Obtained funding: van Leeuwen.
Administrative, technical, or material support: Janus, Krol, Petersen, Raemaekers, Kok.
Study supervision: Schaapveld, Aleman, van Leeuwen.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by grant NKI 2010-4720 from the Dutch Cancer Society (Dr van Leeuwen).
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.
Previous Presentation: An abstract from preliminary analyses of this study was presented at the American Society of Clinical Oncology Annual Meeting; June 3, 2014; Chicago, Illinois.
Additional Contributions: K. Kooijman, MSc, S. Fase, MSc, S. de Vries, MSc, and M. van Wouwe, MD, from The Netherlands Cancer Institute collected data for the study. We are indebted to the thousands of physicians who provided follow-up data for the study. No compensation was provided.