Accepted for Publication: February 23, 2015.
Published Online: April 20, 2015. doi:10.1001/jamainternmed.2015.0930.
Study concept and design: Åsvold, Bjøro, Bauer, Ferrucci, Gussekloo, Maciel, Newman, Razvi, Westendorp, Rodondi.
Acquisition, analysis, or interpretation of data: Åsvold, Bjøro, Bremner, Cappola, Ceresini, den Elzen, Franco, Franklyn, Gussekloo, Iervasi, Imaizumi, Kearney, Khaw, Maciel, Peeters, Psaty, Razvi, Sgarbi, Stott, Trompet, Vanderpump, Völzke, Walsh, Westendorp, Rodondi.
Drafting of the manuscript: Åsvold.
Critical revision of the manuscript for important intellectual content: Vatten, Bjøro, Bauer, Bremner, Cappola, Ceresini, den Elzen, Ferrucci, Franco, Franklyn, Gussekloo, Iervasi, Imaizumi, Kearney, Khaw, Maciel, Newman, Peeters, Psaty, Razvi, Sgarbi, Stott, Trompet, Vanderpump, Völzke, Walsh, Westendorp, Rodondi.
Statistical analysis: Åsvold, Rodondi.
Obtained funding: Åsvold, Ferrucci, Khaw, Maciel, Newman, Sgarbi, Völzke, Walsh, Westendorp, Rodondi.
Administrative, technical, or material support: Bjøro, Ceresini, den Elzen, Ferrucci, Franco, Gussekloo, Khaw, Newman, Peeters, Psaty, Trompet, Völzke.
Study supervision: Vatten, Bjøro, Gussekloo, Stott, Westendorp, Rodondi.
Conflict of Interest Disclosures: Dr Peeters has received lecture and consultancy fees from Genzyme Europe. No other disclosures were reported.
Funding/Support: The Thyroid Studies Collaboration was supported by grants from the Swiss National Science Foundation (SNSF 320030-138267 and 320030-150025) and partially supported by a grant from the Swiss Heart Foundation (all to Dr Rodondi). Dr Åsvold is supported by the Research Council of Norway. The Whickham Survey was supported by the UK Department of Health. The Rotterdam Study is funded by Erasmus MC and Erasmus University, Rotterdam, the Netherlands; the Netherlands Organisation for Scientific Research; the Netherlands Organisation for the Health Research and Development; the Research Institute for Diseases in the Elderly; the Ministry of Education, Culture, and Science; the Ministry for Health, Welfare, and Sports; the European Commission; and the Municipality of Rotterdam. Maryam Kavousi, MD, PhD (Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands), is supported by the AXA Research Fund. Maarten J. G. Leening, MD, MSc, and Bruno H. Stricker, MMed, PhD (both with Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands), are supported by a grant from the Netherlands Organisation for Health Research and Development (HTA grant 80.82500.98.10208). Dr Franco works in ErasmusAGE, a center for aging research across the life course funded by Nestlé Nutrition (Nestec Ltd), Metagenics Inc, and AXA. The Leiden 85-Plus Study was partly funded by the Dutch Ministry of Health, Welfare, and Sports. The Nagasaki Adult Health Study was supported by the Radiation Effects Research Foundation, Hiroshima and Nagasaki, Japan, a private, nonprofit foundation funded by the Japanese Ministry of Health, Labor, and Welfare and the US Department of Energy, the latter in part through the National Academy of Sciences. The Health, Aging, and Body Composition Study was supported by National Institute on Aging (NIA) contracts N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; NIA grant R01-AG028050; and National Institute of Nursing Research grant R01-NR012459. The research was supported in part by the Intramural Research Program of the NHNIA. Principal investigators and staff of the Health, Aging, and Body Composition Study are Anne B. Newman, MD, MPH, and Diane Ives, MPH, University of Pittsburgh; Suzanne Satterfield, MD, DrPH, and Jan Elam, BS, University of Tennessee, Memphis; Steven R. Cummings, MD, Michael C. Nevitt, PhD, and Susan M. Rubin, MPH, University of California, San Francisco; and Tamara B. Harris, MD, and Melissa E. Garcia, MPH, National Institute on Aging. The Cardiovascular Health Study (CHS) is supported by contracts HHSN268201200036C, HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086 as well as grant HL080295 from the National Heart, Lung, and Blood Institute, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through AG-032317 and AG-023629 from the NIA (see also https://chs-nhlbi.org/). The Nord-Trøndelag Health Study (HUNT Study) is a collaborative effort of HUNT Research Center, Faculty of Medicine, Norwegian University of Science and Technology; Nord-Trøndelag County Council; Central Norway Health Authority; and the Norwegian Institute of Public Health. Data were provided by the HUNT Research Center, Statistics Norway, and the Department for Research and Development, Nord-Trøndelag Hospital Trust. The thyroid function testing in the HUNT Study was financially supported by Wallac Oy (Turku, Finland). The EPIC-Norfolk Study was supported by research grants from the Medical Research Council UK and Cancer Research UK. The Brazilian Thyroid Study was supported by an unrestricted grant from the São Paulo State Research Foundation (Fundacão de Amparo à Pesquisa do Estado de São Paulo grant 6/59737-9 to Dr Maciel). The Study of Health in Pomerania is part of the Community Medicine Research net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research, the Ministry of Cultural Affairs, and the Social Ministry of the Federal State of Mecklenburg-West Pomerania. Analyses were further supported by a grant of the German Research Foundation (DFG Vo 955/12-1). The Prospective Study of Pravastatin in the Elderly at Risk study was supported by an investigator-initiated grant obtained from Bristol-Myers Squibb. Dr Jukema is an established clinical investigator of the Netherlands Heart Foundation (grant 2001 D 032). The Osteoporotic Fractures in Men Study is supported by National Institutes of Health (NIH) funding. The following institutes provide support: the NIA, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Center for Advancing Translational Sciences, and NIH Roadmap for Medical Research under the following grant numbers: U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.
Role of the Funder/Sponsor: The National Institute on Aging, which funded the Health, Aging, and Body Composition Study, and the Radiation Effects Research Foundation, which funded the Nagasaki Adult Health Study, reviewed and approved the manuscript. The other funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
The Thyroid Studies Collaboration: Participating studies of the Thyroid Studies Collaboration include the following: United States: Health, Aging, and Body Composition Study, Cardiovascular Health Study, and Osteoporotic Fractures in Men (MrOS) Study. Europe: Whickham Survey, Rotterdam Study, Birmingham Study, Leiden 85-Plus Study, Pisa cohort, HUNT Study (Nord-Trøndelag Health Study), EPIC-Norfolk Study, Study of Health in Pomerania (SHIP), PROSPER trial, and InCHIANTI. Australia: Busselton Health Study. Asia: Nagasaki Adult Health Study. South America: Brazilian Thyroid Study. Members of the Executive Committee: Nicolas Rodondi, MD, MAS (Department of General Internal Medicine, Inselspital, University of Bern, Bern, Switzerland); Jacobijn Gussekloo, MD, PhD (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands); Douglas C. Bauer, MD (Department of Medicine and Department of Epidemiology and Biostatistics, University of California, San Francisco); Anne R. Cappola, MD, ScM (Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia); and Robin P. Peeters, MD, PhD (Rotterdam Thyroid Center, Department of Internal Medicine, Erasmus Medical Center, and Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands). Members of the Steering Committee: Bjørn O. Åsvold, MD, PhD (Department of Public Health, Norwegian University of Science and Technology, and Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway); John P. Walsh, MBBS, FRACP, PhD (Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, and School of Medicine and Pharmacology, The University of Western Australia, Crawley, Western Australia); Jayne A. Franklyn, MD, PhD, FRCP, FMedSci (School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, England); Giorgio Iervasi, MD (National Council Research Institute of Clinical Physiology/Tuscany Region G. Monasterio Foundation, Pisa, Italy); Misa Imaizumi, MD, PhD (Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan); Salman Razvi, MD, FRCP (Department of Endocrinology, Gateshead Health Foundation NHS Trust, Gateshead, England); Kay-Tee Khaw, MD (Department of Public Health and Primary Care, University of Cambridge, Cambridge, England); Henry Völzke, MD (Institute for Community Medicine, Study of Health in Pomerania/Clinical-Epidemiological Research and German Centre of Cardiovascular Research, University of Greifswald, Greifswald, Germany); José A. Sgarbi, MD (Division of Endocrinology, Department of Medicine, Federal University of São Paulo, São Paulo, and Division of Endocrinology, Faculdade de Medicina de Marília, Marília, Brazil); Rudi G. J. Westendorp, MD, PhD (Department of Cardiology, Leiden University Medical Center, and Netherlands Consortium for Healthy Aging, Leiden, the Netherlands, and Department of Public Health, University of Copenhagen, Copenhagen, Denmark); and Graziano Ceresini, MD, PhD (Department of Clinical and Experimental Medicine, Geriatric Endocrine Unit, University Hospital of Parma, Parma, Italy). Members of the Data Management Group: Wendy P. J. den Elzen, PhD (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands); Tinh-Hai Collet, MD (Service of Endocrinology, Diabetes, and Metabolism, University Hospital of Lausanne, Lausanne, Switzerland, and University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom); Bruno da Costa, PhD (Berner Institut für Hausarztmedizin, University of Bern, Bern, Switzerland); Christine Baumgartner, MD (Department of General Internal Medicine, Inselspital, University of Bern, Bern, Switzerland); Manuel Raphael Blum, MD (Department of General Internal Medicine, Inselspital, University of Bern, Bern, Switzerland); and Hendrika Anette van Dorland, PD, DrSc (Department of General Internal Medicine, Inselspital, University of Bern, Bern, Switzerland).