The MANOVA for general clinical and sleep measures showed a significant treatment group × time interaction (F5,73 = 5.99, P < .001), as well as significant group (F5,73 = 2.34, P = .05), and time (F5,73 = 2.34, P < .001) main effects (Table 2). Mixed models indicated significant effects of BBTI and significant differences between BBTI and IC in change scores for depression, sleep quality, and general health. Effect sizes were moderate. No group difference was found for change in anxiety or sleepiness. The MANOVA for the sleep diary domain also indicated significant interaction (F8,70 = 4.32, P < .001) and time effects (F8,70 = 6.65, P < .001) but no significant effect for group (F8,70 = 1.67, P = .12) (Table 3). The BBTI group had later bedtimes, improved sleep quality, and improved SOL, WASO, and SE compared with the IC group, with moderate to large effect sizes. The TST and morning rise time did not show differential effects of the 2 interventions. Significant differential treatment effects were found for actigraphy (MANOVA interaction, F4,74 = 17.72, P < .001; time, F4,74 = 15.37, P < .001; and group, F4,74 = 2.13, P = .09) (Table 4). We found that the BBTI group had a significantly greater reduction in actigraphy-based WASO and SOL and a significantly greater increase in SE compared with the IC group using mixed models. The BBTI group also had a significantly greater reduction in actigraphically measured TST from pretreatment to posttreatment. However, the significant MANOVA interaction was still seen after excluding TST (interaction, F3,75 = 5.85, P = .001). No differential treatment effects were noted for PSG (MANOVA interaction, F4,74 = 1.20, P = .32; time, F4,74 = 3.95, P = .006; group F4,74 = 0.47, P = .76) (Table 5). Sensitivity analyses using natural log and square root transformations in univariate mixed model analyses revealed an identical pattern of significant results.