0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Original Investigation | ONLINE FIRST

Primary Care Clinicians' Experiences With Treatment Decision Making for Older Persons With Multiple Conditions FREE

Terri R. Fried, MD; Mary E. Tinetti, MD; Lynne Iannone, MA
[+] Author Affiliations

Author Affiliations: Department of Medicine (Drs Fried and Tinetti) and Program on Aging (Ms Iannone), Yale School of Medicine, New Haven, Connecticut; and Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare System, West Haven (Dr Fried).


Arch Intern Med. 2010;171(1):75-80. doi:10.1001/archinternmed.2010.318.
Text Size: A A A
Published online

Optimizing the care of older persons with multiple medical conditions is a complex task, with clinicians receiving potentially contradictory recommendations regarding how to tailor care for these patients from the medical literature. On the one hand, there is a growing evidence base that older persons with multiple conditions have poorer outcomes when treated according to disease-specific guidelines compared with other patients.16 There are several reasons for these poorer outcomes. First, the presence of comorbid conditions may result in persons receiving less benefit from therapy directed at a particular condition.1,2 Second, the presence of these conditions may also increase the likelihood that the individual will experience adverse effects with any given intervention.3,4 Finally, the polypharmacy that generally accompanies multimorbidity confers an increased risk of adverse drug events, independent of the chronic conditions.5,6 On the other hand, editorials and clinical studies remind readers that the clinical trials providing the evidence base underlying these guidelines demonstrate that patients have improved outcomes with the medications recommended by these guidelines,7,8 and multiple studies have examined medication underuse and the failure to apply clinical guidelines to individual patients as a problem of poor quality care.911 Clinicians are therefore charged with caring for an increasing number of older patients with multimorbidity in the face of the seemingly contradictory evidence of the harms and benefits of following disease guidelines.

In the face of this complexity, new approaches are needed to guide the care of older persons with multiple conditions. Ideally, the design of these approaches will not only incorporate the best evidence regarding how multimorbidity influences the outcomes of treatment but also be responsive to the needs and perspectives of the clinicians who provide the care for these patients. Little is known about how clinicians approach the care of older persons with multiple medical conditions. Understanding clinicians' experiences with these patients and their views on the challenges inherent to their care can help to inform the development of approaches that are acceptable to clinicians and are congruent with their practice patterns. The purpose of this study was to explore clinicians' perspectives of and experiences with therapeutic decision making for older persons with multiple medical conditions. Because we were interested in understanding how clinicians think about the care they provide, we used qualitative methods to allow participants to articulate the reasoning and strategies they use.

PARTICIPANTS

The participants were clinicians who had completed training and who belonged to general internal medicine primary care practices. We purposefully sampled practices from academic, community, and Veterans Affairs (VA) settings in the greater New Haven, Connecticut, area to ensure the inclusion of participants who were practicing medicine under different care systems and who had a diverse set of constraints informing their approach to the care of older persons with multiple conditions. Five focus groups were conducted. Of these, 2 were conducted with community primary care practices, 1 of which consisted of 3 physicians and a nurse practitioner; the second group consisted of 3 physicians. There were 2 focus groups conducted with the primary care practices of the VA Connecticut Healthcare System, West Haven. The first of these focus groups consisted of 7 physicians and 1 pharmacist, 1 nurse practitioner, and 1 physician assistant, and the second focus group consisted of 3 physicians. The final focus group was conducted with the full-time general medicine faculty members at Yale School of Medicine, New Haven. This group consisted of 20 physicians who had widely varying distributions in the time that they spent performing clinical work, administration, and research and whose practice sites included primary care clinics at several urban hospitals and the VA Connecticut Healthcare System. Participants received a meal but no other reimbursement. The study protocol was approved by the Human Investigation Committee of the Yale School of Medicine and the Human Subjects Subcommittee of the VA Connecticut Healthcare System.

DATA COLLECTION

The focus groups were moderated by a single investigator (T.R.F.), who used a discussion guide. The guide began with an opening statement informing participants that they were asked to participate because of their experience in caring for older persons with multiple medical conditions and that they would be asked to talk about the approaches they took in caring for this population of patients. The first questions asked participants to think broadly about treatment decision making for these patients. The participants were asked to think about their patients who had multiple medical conditions and were potentially taking multiple medications and to reflect on how their approach to treatment decision making compared with their approach for younger patients and patients without multiple conditions. They were also asked to think about how they applied clinical guidelines to these patients and whether there were patient factors that influenced the way in which they used the guidelines.

The follow-up questions were designed to serve as prompts to promote additional discussion related to treatment decision making. The participants were asked (1) what they believed to be the status of evidence used to inform the care of this group of patients; (2) about their approach to polypharmacy in this patient population; and (3) about their approach to the patient who, after being prescribed a medication as recommended by clinical guidelines, such as a statin for hyperlipidemia, returned with a symptom attributed by the patient to the medication. The focus group sessions lasted approximately 60 minutes.

DATA ANALYSIS

The focus groups were audiotaped and transcribed by an experienced medical transcriptionist. Content analysis was used to code small portions of the text representing unique concepts. Initially, 2 investigators independently coded 2 of the focus group transcripts and developed a coding structure. The structure was developed inductively, as codes were assigned based on repeated close readings of the text. The investigators met to compare the structures and their application to the text. Differences in both the identification of codes and the application of codes to text were resolved through discussion. A single investigator coded the remaining transcripts, and 2 investigators met to discuss the relationship of the codes to one another within and across transcripts to identify themes arising from the examination of the relationships among the codes.

OVERVIEW

A number of themes were identified that described clinicians' approaches to treatment decision making for older persons with multiple medical conditions. These were (1) concerns about patients' ability to adhere to complex medical regimens; (2) variability in beliefs regarding the harms and benefits of guideline-directed care; (3) variability in approaches to balancing trade-offs between harms and benefits; (4) involvement of patients in the decision-making process; and (5) barriers to clinicians' preferred approaches to decision making.

CONCERNS ABOUT PATIENTS’ ABILITY TO ADHERE TO COMPLEX MEDICAL REGIMENS

Participants in every focus group cited examples of tailoring their approach to the care of older persons with multiple conditions because of concerns that the patients would not be able to adhere to more complex regimens. These concerns stemmed from a consideration of such factors as patients' cognition and availability of social support (Figure 1).

Place holder to copy figure label and caption
Figure 1.

Concerns about older persons' ability to adhere to complex medication regimens, leading to modification of treatment.

Graphic Jump Location
VARIABILITY IN BELIEFS REGARDING THE HARMS AND BENEFITS OF GUIDELINE-DIRECTED CARE

In contrast to the consensus about the need to tailor therapy based on the patient's ability to adhere, there was substantial variability in beliefs about the likelihood of the benefits vs the harms of guideline-directed care. Some clinicians cited concerns about the possibility of the harms outweighing the benefits of guideline-directed care, whereas other clinicians believed that guideline-directed care would produce the best outcomes (Figure 2). Clinicians also raised concerns about the lack of data regarding the benefits vs the harms of this care and about the focus of guidelines on outcomes that might not be of greatest importance to their patients. Participants who raised issues of the trade-offs between the benefits and the harms or of the lack of data spoke of these issues as reasons to deviate from guideline-directed care.

Place holder to copy figure label and caption
Figure 2.

Differing interpretations regarding harms and benefits of guideline-directed care.

Graphic Jump Location
VARIABILITY IN APPROACHES TO BALANCING TRADE-OFFS BETWEEN THE HARMS AND THE BENEFITS OF GUIDELINE-DIRECTED CARE

Those clinicians who were concerned about the trade-offs between the benefits and the harms of guideline-directed care had a wide variety of approaches as to how they could be balanced. These different approaches and representative quotations included prioritizing the patient's problems, stratifying risk for individual diseases, and modifying guidelines in anticipation of certain adverse effects (Figure 3). Clinicians also spoke about the lack of available tools to help them quantify benefits and harms as well as about their inability at times to find a strategy for balancing benefits and harms.

Place holder to copy figure label and caption
Figure 3.

Variability in approaches to balancing trade-offs and competing outcomes.

Graphic Jump Location
INVOLVEMENT OF PATIENTS IN THE DECISION-MAKING PROCESS

Clinicians offered differing descriptions of how they involved their older patients in the process of decision making (Figure 4). Several clinicians spoke of conflicts between what they wanted to do for the patient and what the patient wanted, and they presented different approaches to dealing with these differing goals.

Place holder to copy figure label and caption
Figure 4.

Involvement of patients in the decision-making process.

Graphic Jump Location
BARRIERS TO CLINICIANS’ PREFERRED APPROACHES TO DECISION MAKING

Regardless of how they balanced competing outcomes and attempted to involve patients in the decision-making process, the clinicians cited a number of barriers to making what they identified as being the highest-quality decisions for or with their patients (Figure 5). These barriers included unrealistic patient and family expectations, the questionable application of quality measures, involvement of specialists, and lack of time and reimbursement.

Place holder to copy figure label and caption
Figure 5.

Barriers to clinicians' preferred approaches to decision making.

Graphic Jump Location
VIEWS OF ACADEMIC VS COMMUNITY CLINICIANS

Each of the major themes and specific examples arose in at least 1 focus group that was composed of academic clinicians and at least 1 that was composed of community clinicians, with 1 exception. The issue of quality measures was raised only by clinicians in the focus groups conducted at the VA Connecticut Healthcare System.

The perspectives of primary care clinicians regarding the treatment of their older patients with multiple medical conditions highlight the complexity of caring for this group of patients. The clinicians' experiences suggest that they struggle with the uncertainties of applying disease-specific guidelines to their older patients with multiple conditions and creating strategies for optimizing decision making and improving patient outcomes. Many clinicians were concerned about their patients' ability to adhere to complicated medical regimens. There were variable beliefs regarding the benefits and harms of guideline-directed care. While some clinicians believed that this approach would provide the best outcomes, others were concerned (1) that guidelines were developed based on evidence obtained from younger patients; (2) that they failed to target outcomes of greatest concern to their patients, such as quality of life; and (3) that the application of multiple guidelines could result in adverse events. The participants used a variety of strategies to balance the benefits and harms of guideline-directed care, including prioritizing the patient's problem list and performing risk stratification for individual diseases, but they also cited the lack of availability of outcome data and noted that they sometimes could not figure out how to achieve a balance. They cited conflicts in their own and their patients' goals, and they varied in their approach to resolving them. They identified a number of barriers to caring for older patients with multimorbidity, including unrealistic patient and family expectations, pressure to adhere to quality measures, and lack of time and reimbursement.

The considerations expressed by clinicians in this study reflect the current concerns, debates, and uncertainty in the growing medical literature on the care of older persons with multiple conditions. Their experiences illustrate that apprehensions about the potential adverse consequences of guideline-directed care are not merely theoretical,4 but rather are being observed by clinicians caring for older persons with multiple conditions and are influencing treatment decision making. These observations corroborate previous reports of the limitations of currently conducted randomized clinical trials to detect the full range of adverse effects of treatments in older adults with multimorbidity.12 There is growing evidence from cohort studies to suggest that these adverse effects include ones not traditionally associated with medications, as, for example, the association between number of medications taken and weight loss and impaired balance.6 The comments of 1 clinician also highlighted the notion that traditionally studied outcomes, such as mortality, may not be the outcomes of greatest importance to patients. This observation is supported by studies of older persons demonstrating the importance of outcomes such as maintaining physical and cognitive function and relief of symptoms.1315 Clinicians in this study, however, also pointed to guideline-directed care as based on the best available evidence for optimizing outcomes in older persons with multiple conditions. The variability in clinicians' views on the applicability of disease guidelines to their older patients with multimorbidity and the benefits and harms associated with guideline-directed care reflects the ongoing uncertainty regarding the clinical strategies that will provide the best outcomes.16 In addition to the studies demonstrating the risk of adverse outcomes associated with guideline-directed care, evidence also suggests that the patients who are at the highest risk for these adverse outcomes may also be the ones most likely to derive benefit from the intervention.17

Clinicians' descriptions of how they involve patients in the decision-making process illustrate the challenges of implementing the principles of patient-centered care. These descriptions included the negotiation between patients' and clinicians' values and goals, which were characterized as sometimes being in conflict. Implicit in the decision-making process for some clinicians was the belief that any amount of risk reduction for a given disease-specific outcome, such as myocardial infarction, warranted intervention. However, some studies have demonstrated that, when presented with numerical data regarding risk reduction, many patients would be willing to take medication only if the amount of risk reduction exceeded the actual benefit provided by commonly prescribed therapies.18,19 Moreover, other clinicians noted that the reduction in risk for a disease-specific outcome might not be what was most important to the patient, an observation supported by studies indicating that the adverse effects of medications may be as, if not more, important to patients than their primary effects.20,21 Disagreement between patients or caregivers and clinicians regarding the goals for an individual patient's care has also been demonstrated quantitatively.22,23 Although the authors of these studies suggest that these findings indicate a lack of clinicians' awareness of the patient's priorities, the clinicians in the present study presented a more complex picture. They cited concern about patients' and families' inaccurate understanding of harms and benefits, and they described performing testing to help patients understand their risk.

The results of our study suggest that clinicians would benefit from a number of tools to assist them in decision making for older persons with multiple conditions. First, the concept of tailoring therapy based on a consideration of patients' ability to adhere has not received much attention in the medical literature. Such tailoring suggests the need for explicit assessment of the complexity of the interventions recommended by clinical guidelines and for simplified alternatives, so that patients and their families can be provided with treatment plans that are feasible for them to accomplish. Second, the clinicians who discussed the absence of risk calculators for patients with multiple conditions highlight the need for the development of methods to provide individualized assessments of harm vs benefit associated with different treatment strategies in order to determine optimal therapy depending on a patient's comorbidity profile.24,25 Finally, clinicians' efforts to inform and involve their patients in the decision-making process suggest that, despite the advances made in risk communication26 and shared and informed decision making,27 further work is required to create and disseminate clinical tools that are suitable for use in primary care practice to elicit priorities and goals in ways that ensure that both clinicians and patients and families feel that they have been understood.

The results also highlight the system and health policy challenges that must be met to improve the process of decision making. The experience of the clinicians who feel pressure to modify their practice based on their exposure to clinical reminders and quality measures supports efforts for modifying these metrics for persons with multiple conditions.28 The primary care clinicians' concerns that their subspecialist colleagues may not consider the wider harms and benefits of organ-specific intervention reflect the fragmentation of care for patients who receive care for their multiple conditions from many physicians. It is important to find a way to provide patients with a unified approach to decision making that incorporates the perspectives of different clinicians. The final challenge concerns the limitations imposed by current reimbursement systems, which, as described by several participants, fail to acknowledge the complexities of caring for older persons with multiple conditions.

Because of the qualitative methods used in this study, conclusions cannot be drawn regarding the prevalence of clinicians' attitudes or regarding differences in these attitudes according to the nature or site of their practice. Although the study population included clinicians practicing in both academic and community settings, it is possible that clinicians agreeing to participate in a focus group may not be representative of all primary care clinicians. To decrease the burden on clinicians and to encourage their participation, we did not take additional time to collect descriptive information; therefore, we are unable to characterize our participants in terms of their own characteristics or those of their practices. Several of the probes used in the discussion guide, such as asking clinicians their response to a patient who develops an adverse effect to a medication, were not specific to the care of the older person. Notably, the inclusion of such questions resulted in several participants observing that their approach to balancing the benefits and harms of medications in older persons could be appropriate for many other patients in their practice.

The primary care clinicians represented in this qualitative study recognize the complexities of caring for older persons with multiple conditions and the need to provide individually tailored therapy. According to their own reports, they need more data, alternative guidelines, approaches to incorporating their patients' values, the support of their subspecialist colleagues, and an altered reimbursement system to accomplish this task. Addressing these needs will not be easy, but it is essential if we are to evolve a health care system designed to effectively and efficiently care for the ever-increasing number of older patients with multiple chronic diseases.

Correspondence: Terri R. Fried, MD, Clinical Epidemiology Research Center 151B, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516 (terri.fried@yale.edu).

Accepted for Publication: July 7, 2010.

Published Online: September 13, 2010. doi: 10.1001/archinternmed.2010.318

Author Contributions: Dr Fried had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Fried and Tinetti. Acquisition of data: Fried and Ianonne. Analysis and interpretation of data: Fried, Tinetti, and Ianonne. Drafting of the manuscript: Fried. Critical revision of the manuscript for important intellectual content: Tinetti and Ianonne. Obtained funding: Fried. Administrative, technical, and material support: Ianonne.

Financial Disclosure: None reported.

Funding/Support: This study was supported in part by grant Pioneer 58381 from the Robert Wood Johnson Foundation and by the Claude D. Pepper Older Americans Independence Center at Yale School of Medicine (P30AG21342 NIH/NIA). Dr Fried is supported by grant K24 AG028443 NIH/NIA.

Huang  ESZhang  QGandra  NChin  MHMeltzer  DO The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis. Ann Intern Med 2008;149 (1) 11- 19
PubMed Link to Article
Greenfield  SBillimek  JPellegrini  F  et al.  Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study. Ann Intern Med 2009;151 (12) 854- 860
PubMed Link to Article
Tinetti  MEBogardus  ST  JrAgostini  JV Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med 2004;351 (27) 2870- 2874
PubMed Link to Article
Boyd  CMDarer  JBoult  CFried  LPBoult  LWu  AW Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 2005;294 (6) 716- 724
PubMed Link to Article
Field  TSGurwitz  JHHarrold  LR  et al.  Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc 2004;52 (8) 1349- 1354
PubMed Link to Article
Agostini  JVHan  LTinetti  ME The relationship between number of medications and weight loss or impaired balance in older adults. J Am Geriatr Soc 2004;52 (10) 1719- 1723
PubMed Link to Article
Gurwitz  JHRochon  P Improving the quality of medication use in elderly patients: a not-so-simple prescription. Arch Intern Med 2002;162 (15) 1670- 1672
PubMed Link to Article
Gurwitz  JH Polypharmacy: a new paradigm for quality drug therapy in the elderly? Arch Intern Med 2004;164 (18) 1957- 1959
PubMed Link to Article
Sloane  PDGruber-Baldini  ALZimmerman  S  et al.  Medication undertreatment in assisted living settings. Arch Intern Med 2004;164 (18) 2031- 2037
PubMed Link to Article
Steinman  MALandefeld  CSRosenthal  GEBerthenthal  DSen  SKaboli  PJ Polypharmacy and prescribing quality in older people. J Am Geriatr Soc 2006;54 (10) 1516- 1523
PubMed Link to Article
Sales  AETipton  EFLevine  DA  et al.  Are co-morbidities associated with guideline adherence? the MI-Plus study of Medicare patients. J Gen Intern Med 2009;24 (11) 1205- 1210
PubMed Link to Article
Vandenbroucke  JPPsaty  BM Benefits and risks of drug treatments: how to combine the best evidence on benefits with the best data about adverse effects. JAMA 2008;300 (20) 2417- 2419
PubMed Link to Article
Rosenfeld  KEWenger  NSKagawa-Singer  M End-of-life decision making: a qualitative study of elderly individuals. J Gen Intern Med 2000;15 (9) 620- 625
PubMed Link to Article
Gillick  MBerkman  SCullen  L A patient-centered approach to advance medical planning in the nursing home. J Am Geriatr Soc 1999;47 (2) 227- 230
PubMed
Fried  TRBradley  EHTowle  VRAllore  H Understanding the treatment preferences of seriously ill patients. N Engl J Med 2002;346 (14) 1061- 1066
PubMed Link to Article
Ritchie  C Health care quality and multimorbidity: the jury is still out. Med Care 2007;45 (6) 477- 479
PubMed Link to Article
Gage  BFBirman-Deych  EKerzner  RRadford  MJNilasena  DSRich  MW Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall. Am J Med 2005;118 (6) 612- 617
PubMed Link to Article
Murphy  DJGahm  GJSantilli  SNorth  POliver  SCShapiro  H Seniors' preferences for cancer screening and medication use based on absolute risk reduction. J Gerontol A Biol Sci Med Sci 2002;57 (2) M100- M105
PubMed Link to Article
Llewellyn-Thomas  HAPaterson  JMCarter  JA  et al.  Primary prevention drug therapy: can it meet patients' requirements for reduced risk? Med Decis Making 2002;22 (4) 326- 339
PubMed Link to Article
Belcher  VNFried  TRAgostini  JVTinetti  ME Views of older adults on patient participation in medication-related decision making. J Gen Intern Med 2006;21 (4) 298- 303
PubMed Link to Article
Fried  TRMcGraw  SAgostini  JVTinetti  ME Views of older persons with multiple morbidities on competing outcomes and clinical decision-making. J Am Geriatr Soc 2008;56 (10) 1839- 1844
PubMed Link to Article
Bogardus  STBradley  EHWilliams  CSMaciejewski  PKvan Doorn  CInouye  SK Goals for the care of frail older adults: do caregivers and clinicians agree? Am J Med 2001;110 (2) 97- 102
PubMed Link to Article
Zulman  DMKerr  EAHofer  TPHeisler  MZikmund-Fisher  BJ Patient-provider concordance in the prioritization of health conditions among hypertensive diabetes patients. J Gen Intern Med 2010;25 (5) 408- 414
PubMed Link to Article
Murphy  TEAgostini  JVVan Ness  PHPeduzzi  PTinetti  MEAllore  HG Assessing multiple medication use with probabilities of benefits and harms. J Aging Health 2008;20 (6) 694- 709
PubMed Link to Article
Fraenkel  LFried  TR Individualized medical decision making: necessary, achievable, but not yet attainable. Arch Intern Med 2010;170 (6) 566- 569
PubMed Link to Article
Apter  AJPaasche-Orlow  MKRemillard  JT  et al.  Numeracy and communication with patients: they are counting on us. J Gen Intern Med 2008;23 (12) 2117- 2124
PubMed Link to Article
Coulter  AEllins  J Effectiveness of strategies for informing, educating, and involving patients. BMJ 2007;335 (7609) 24- 27
PubMed Link to Article
Walter  LCDavidowitz  NPHeineken  PACovinsky  KE Pitfalls of converting practice guidelines into quality measures: lessons learned from a VA performance measure. JAMA 2004;291 (20) 2466- 2470
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

Concerns about older persons' ability to adhere to complex medication regimens, leading to modification of treatment.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Differing interpretations regarding harms and benefits of guideline-directed care.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Variability in approaches to balancing trade-offs and competing outcomes.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Involvement of patients in the decision-making process.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 5.

Barriers to clinicians' preferred approaches to decision making.

Graphic Jump Location

Tables

References

Huang  ESZhang  QGandra  NChin  MHMeltzer  DO The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis. Ann Intern Med 2008;149 (1) 11- 19
PubMed Link to Article
Greenfield  SBillimek  JPellegrini  F  et al.  Comorbidity affects the relationship between glycemic control and cardiovascular outcomes in diabetes: a cohort study. Ann Intern Med 2009;151 (12) 854- 860
PubMed Link to Article
Tinetti  MEBogardus  ST  JrAgostini  JV Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med 2004;351 (27) 2870- 2874
PubMed Link to Article
Boyd  CMDarer  JBoult  CFried  LPBoult  LWu  AW Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA 2005;294 (6) 716- 724
PubMed Link to Article
Field  TSGurwitz  JHHarrold  LR  et al.  Risk factors for adverse drug events among older adults in the ambulatory setting. J Am Geriatr Soc 2004;52 (8) 1349- 1354
PubMed Link to Article
Agostini  JVHan  LTinetti  ME The relationship between number of medications and weight loss or impaired balance in older adults. J Am Geriatr Soc 2004;52 (10) 1719- 1723
PubMed Link to Article
Gurwitz  JHRochon  P Improving the quality of medication use in elderly patients: a not-so-simple prescription. Arch Intern Med 2002;162 (15) 1670- 1672
PubMed Link to Article
Gurwitz  JH Polypharmacy: a new paradigm for quality drug therapy in the elderly? Arch Intern Med 2004;164 (18) 1957- 1959
PubMed Link to Article
Sloane  PDGruber-Baldini  ALZimmerman  S  et al.  Medication undertreatment in assisted living settings. Arch Intern Med 2004;164 (18) 2031- 2037
PubMed Link to Article
Steinman  MALandefeld  CSRosenthal  GEBerthenthal  DSen  SKaboli  PJ Polypharmacy and prescribing quality in older people. J Am Geriatr Soc 2006;54 (10) 1516- 1523
PubMed Link to Article
Sales  AETipton  EFLevine  DA  et al.  Are co-morbidities associated with guideline adherence? the MI-Plus study of Medicare patients. J Gen Intern Med 2009;24 (11) 1205- 1210
PubMed Link to Article
Vandenbroucke  JPPsaty  BM Benefits and risks of drug treatments: how to combine the best evidence on benefits with the best data about adverse effects. JAMA 2008;300 (20) 2417- 2419
PubMed Link to Article
Rosenfeld  KEWenger  NSKagawa-Singer  M End-of-life decision making: a qualitative study of elderly individuals. J Gen Intern Med 2000;15 (9) 620- 625
PubMed Link to Article
Gillick  MBerkman  SCullen  L A patient-centered approach to advance medical planning in the nursing home. J Am Geriatr Soc 1999;47 (2) 227- 230
PubMed
Fried  TRBradley  EHTowle  VRAllore  H Understanding the treatment preferences of seriously ill patients. N Engl J Med 2002;346 (14) 1061- 1066
PubMed Link to Article
Ritchie  C Health care quality and multimorbidity: the jury is still out. Med Care 2007;45 (6) 477- 479
PubMed Link to Article
Gage  BFBirman-Deych  EKerzner  RRadford  MJNilasena  DSRich  MW Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall. Am J Med 2005;118 (6) 612- 617
PubMed Link to Article
Murphy  DJGahm  GJSantilli  SNorth  POliver  SCShapiro  H Seniors' preferences for cancer screening and medication use based on absolute risk reduction. J Gerontol A Biol Sci Med Sci 2002;57 (2) M100- M105
PubMed Link to Article
Llewellyn-Thomas  HAPaterson  JMCarter  JA  et al.  Primary prevention drug therapy: can it meet patients' requirements for reduced risk? Med Decis Making 2002;22 (4) 326- 339
PubMed Link to Article
Belcher  VNFried  TRAgostini  JVTinetti  ME Views of older adults on patient participation in medication-related decision making. J Gen Intern Med 2006;21 (4) 298- 303
PubMed Link to Article
Fried  TRMcGraw  SAgostini  JVTinetti  ME Views of older persons with multiple morbidities on competing outcomes and clinical decision-making. J Am Geriatr Soc 2008;56 (10) 1839- 1844
PubMed Link to Article
Bogardus  STBradley  EHWilliams  CSMaciejewski  PKvan Doorn  CInouye  SK Goals for the care of frail older adults: do caregivers and clinicians agree? Am J Med 2001;110 (2) 97- 102
PubMed Link to Article
Zulman  DMKerr  EAHofer  TPHeisler  MZikmund-Fisher  BJ Patient-provider concordance in the prioritization of health conditions among hypertensive diabetes patients. J Gen Intern Med 2010;25 (5) 408- 414
PubMed Link to Article
Murphy  TEAgostini  JVVan Ness  PHPeduzzi  PTinetti  MEAllore  HG Assessing multiple medication use with probabilities of benefits and harms. J Aging Health 2008;20 (6) 694- 709
PubMed Link to Article
Fraenkel  LFried  TR Individualized medical decision making: necessary, achievable, but not yet attainable. Arch Intern Med 2010;170 (6) 566- 569
PubMed Link to Article
Apter  AJPaasche-Orlow  MKRemillard  JT  et al.  Numeracy and communication with patients: they are counting on us. J Gen Intern Med 2008;23 (12) 2117- 2124
PubMed Link to Article
Coulter  AEllins  J Effectiveness of strategies for informing, educating, and involving patients. BMJ 2007;335 (7609) 24- 27
PubMed Link to Article
Walter  LCDavidowitz  NPHeineken  PACovinsky  KE Pitfalls of converting practice guidelines into quality measures: lessons learned from a VA performance measure. JAMA 2004;291 (20) 2466- 2470
PubMed Link to Article

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 48

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
JAMAevidence.com

Users' Guides to the Medical Literature
Chapter 22.2. Decision Making and the Patient

Users' Guides to the Medical Literature
The Role of Costs in Clinical Decision Making Remains Controversial